Skip to content
  • Knowledge Hub
  • Careers
  • News & Events
  • Contact Us
CatSci CatSci
  • Home
  • Who we are
  • What we do
    • Small Molecule
      Early Development
    • Small Molecule
      Late Development
    • Oligonucleotides
  • SmartPath
  • Digital Walkthrough
  • Knowledge Hub
  • Careers
  • News & Events
  • Contact Us

Case Studies

Discover the CatSci Case Studies to see how we solve our customers’ dynamic portfolio challenges.

Categories
BlogBook ChaptersCase StudiesPapersPatentsPresentationsThought LeadersWebinarsWhitepapers
Tags
Analytical Chemistry Analytical Science Artificial Intelligence (AI) Biocatalysis Catalysis CatSci Paper CatSci Patent Chemical Development Design of Experiments Digital Drug Development Experimental Design Green Chemistry Industry insights Innovation Machine Learning (ML) Material Science Medium Throughput Experimentation Oligonucleotides Principal Component Analysis Process R&D QbD Route Scouting and Selection Scale-up Scavenging Solvents Sustainability Technology transfer Work-up
Understanding the Polymorph Landscape of an API

A polymorph screen was performed to gain better understanding of the polymorph landscape of an API.

2023 By CatSci team
Deploying AI Enabled Video to Better Understand Crystallisation Events

The CatSci team was set the task of developing a robust scalable manufacturing process suitable for transferring to plant. Discover how they used Lumi, an AI computer vision tool, to monitor and record the reaction, which enabled us to make critical decisions more efficiently and effectively.

2023 By Emmanuelle Juan
Developing a Crystallisation for a Disaccharide

CatSci's material science team was tasked with developing a crystallization for a disaccharide that was produced from an enzymatic reaction.

2022 By Robert DennehyElise RochetteMarc Hutchby
Fast UHPLC methods as a platform technology for expedited PR&D decision-making

CatSci's analytical team facilitated the development and deployment of an efficient and fast UHPLC method screening protocol.

2021 By Siân M. ForsythBeth Rees-HindleyDuncan ThompsonGareth Tutton
Transformation and Visualisation of High Quantities of Analytical Data Made Easy

CatSci’s analytical team employed Knime, a data analytics open source software to automate the transformation, visualisation and reporting of analytical data retrieved from the high throughput process development of a chiral synthetic step.

2021 By Siân M. ForsythBeth Rees-HindleyGareth Tutton
Method Development for High Throughput Sample Analysis

CatSci was tasked with catalyst screening for an asymmetrical hydrogenation of a target.

2021 By Siân M. ForsythBeth Rees-HindleyGareth Tutton
Novel Bromination Process Slashes PMI

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

2021 By Guy BrenchleyDan RichardsJoanne B. SampsonMonica Trues-Suarez
Route Redesign to Eliminate Use of PhOCN

The route supplied by the client involved the use of phenyl cyanate for functionalising a heterocyclic intermediate with a nitrile group. Its ongoing use would require cyanide monitoring, a dedicated waste stream treatment step, and there were concerns over the sourcing of material of appropriate quality over the long term.

2021 By Marc HutchbyFil RotaGareth TuttonNadia Fleary-Roberts
Designing a Robust Scalable Catalytic Process

The client's Phase 1 process was struggling to deliver API in low kg qualities. In particular, Intermediate B was of variable quality, and residual metals were known to negatively affect the onward chemistry.

2020 By Vargini ThangavadivaleDan A. SmithSiân M. Forsyth
Solubility Data-Driven Workup Design & Crystallisation Development

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

2020 By Dan A. SmithAndrew RobertsAntonio M. RudaNadia Fleary-Roberts
Effective Route Scouting Allows Pilot Plant Slot To Be Met

CatSci was tasked with performing route-scouting, route selection and early-phase process development over a 6-month period to meet a pilot plant manufacturing slot.

2020 By Guy BrenchleyElise RochetteJoanne B. SampsonMarc Hutchby
Development of a Late-Stage Buchwald Amination

CatSci was tasked with the development of a regioselective Buchwald-Hartwig amination for the final bond forming step of an API. The inherited conditions were not robust with respect to reaction conversion leading to stability concerns.

2020 By Siân M. ForsythBeth Rees-HindleyJonathan D. MoseleyJoseph Renny

Helpful Links

  • Contact Us
  • Careers
  • Safety, Health and Environment
  • Privacy Policy
  • ESG Report 2022

What we do

  • What we do
    • Late Development
    • Early Development

Who we are

CatSci Ltd are an award-winning innovation partner for medicines development who are committed to creating tailored solutions from candidate selection through product launch and beyond. We break down the silos in drug development to accelerate the delivery of life-changing medicines to patients in need. 

© 2023 CatSci Ltd. All rights reserved.
Registered in England & Wales.
Company No. 07466141.