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Pharmaceutical innovation partner providing process chemistry solutions to support the delivery of best-in-class small molecules, TACS, glues, oligonucleotides and other complex synthetic medicines.
Who are CatSci
We are an award-winning, fast-growing and agile innovation partner with a proven track record in developing economically and environmentally sustainable pharmaceutical manufacturing processes for global companies of all sizes.
Every day, we leverage our fully integrated process chemistry, GMP-analytical science, pre-formulation, material science, HPAPIs, oligonucleotides and new modalities teams along with our state-of-the-art facilities and refined workflows to deliver perfect-for-purpose solutions that balance timelines and internal resources with maximum flexibility.
Our end-in-mind approach enables our customers to meet their ever-evolving portfolio needs.
What CatSci do
As a commercially-minded and scientifically led innovation partner for medicines development, we have been trusted for over a decade to deliver perfect-for-purpose CMC development programmes from small molecules, TACS and glues to oligonucleotides and other complex medicines for customers from across the globe.
We are committed to acting as a real extension of your team and being truly aligned to your internal systems and processes.
Using our end-in-mind approach, passion for science and commitment to innovative thinking, we help you deliver your pharmaceutical pipeline without surprises or delays.
Learn more about CatSci
CatSci’s purpose is to get new medicines into the hands of patients in needs. Find out more about our story and passion to accelerating medicines development here.
Partnering from pre-clinical to product launch
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Chemical Development
Route scouting & selection
Rapid route development & scale-up
Thermal hazard identification & mitigation
Green chemistry exploitation
Kilo-scale non-GMP & GMP material supply
Knowledge transfer for first GMP manufacture
Process design, development & optimisation
Process understanding & robustness for manufacturability
Model-led exploration of design space for process definition
Sustainability metrics
Demonstration batches
Kilo to tonne GMP material supply
Technology transfer for late-stage & commercial manufacture
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Analytical Excellence
High-throughput reaction profiling and analysis
Method development (In-silico, screening optimisation & qualification)
Impurity identification & characterisation
Forced degradation studies
Screening
SFC
Chiral
EPSA
ChromLogD
Large scale purification
Drug substance & product batch analysis (GMP)
Method validation & robustness (following ICHQ14)
Measurement of trace genotoxic impurities & trace element analysis, detailed reaction understanding & data visualisation
Stability studies
Impurity isolation
Oligonucleotide sequencing, characterisation & analysis
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Crystallisation, Solid State & Preformulation
Early solid state characterisation
Version (salt) screening & selection
Polymorph screening
Crystallisation design
Developability assessment
Pre-formulation including formulation definition for pre-clinical studies
Particle & formulation risk assessment for FTIH
Computational assessment using CCDC informatics tools
Micronisation assessment
Crystallisation development & optimisation
QbD process understanding & robustness
Control strategy for solid state & bulk properties
Comprehensive physical properties measurement capability
PAT using in-situ particle measurement & imaging
Filtration & washing optimisation
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Catalysis Experience
Reaction screening & catalyst selection, incl. high pressure reactions & biocatalysis
State-of-the-art expertise in homogeneous & heterogeneous catalysis, incl. asymmetric hydrogenation
Medium-throughput & data-rich experimental workflows
Research, development & optimisation of catalytic processes
Statistical experimental design (DoE, PCA)
Advanced data science & visualisation techniques
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High Potency API Development
Route design
Process invention & characterisation
Crystallisation, isolation & drying
Analytical method development & sample analysis
Up to 10g-scale non-GMP material supply
SafeBridge®-certified laboratory
Parallel reactor workstation technology
Process data collection
Up to 10g-scale non-GMP material supply
Analytical method development & sample analysis
SafeBridge®-certified laboratory
