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Tag filter: Process R&D

Blog Book Chapters Case Studies Papers Patents Presentations Thought Leaders Webinars Whitepapers Press

    Tags

    • Biocatalysis (6)
    • Catalysis (15)
    • CatSci Paper (14)
    • CatSci Patent (2)
    • Design of Experiments (2)
    • Experimental Design (2)
    • Green Chemistry (27)
    • Material Science (5)
    • OPR&D (2)
    • Post-approval Life Cycle Management (1)
    • Principal Component Analysis (3)
    • Process R&D (22)
    • QbD (1)
    • Route Scouting and Selection (2)
    • Scale-up (12)
    • Scavenging (2)
    • Solvents (4)

January, 2021

Novel Bromination Process slashes PMI

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

January, 2021

Route Redesign to Eliminate Use of PhOCN

The route supplied by the client involved the use of phenyl cyanate for functionalising a heterocyclic intermediate with a nitrile group. Its ongoing use would require cyanide monitoring, a dedicated waste stream treatment step, and there were concerns over the sourcing of material of appropriate quality over the long term.

December, 2020

Development of a Late-Stage Buchwald Amination

CatSci was tasked with the development of a regioselective Buchwald-Hartwig amination for the final bond forming step of an API. The inherited conditions were not robust with respect to reaction conversion leading to stability concerns.

December, 2020

Designing a Robust Scalable Catalytic Process

The client's Phase 1 process was struggling to deliver API in low kg qualities. In particular, Intermediate B was of variable quality, and residual metals were known to negatively affect the onward chemistry

December, 2020

Solubility Data Driven Workup Design & Crystallisation Development

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

December, 2020

Effective Route Scouting allows Pilot Plant Slot to be met

CatSci was tasked with performing route-scouting, route selection and early-phase process development over a 6-month period to meet a pilot plant manufacturing slot.

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