The client's Phase 1 process was struggling to deliver API in low kg qualities. In particular, Intermediate B was of variable quality, and residual metals were known to negatively affect the onward chemistry.
Categories
Tags
Analytical Chemistry
Analytical Science
Artificial Intelligence (AI)
Biocatalysis
Catalysis
CatSci Paper
CatSci Patent
Chemical Development
Design of Experiments
Digital
Drug Development
Experimental Design
Green Chemistry
Industry insights
Innovation
Machine Learning (ML)
Material Science
Medium Throughput Experimentation
Oligonucleotides
Principal Component Analysis
Process R&D
QbD
Route Scouting and Selection
Scale-up
Scavenging
Solvents
Sustainability
Technology transfer
Work-up
Optimisation of an Acid-mediated Rearrangement with DoE