• Knowledge Hub
  • News & Events
  • Careers
  • Contact Us
CatSci Logo

  • Home
  • Who we are
  • What we do
    • Early Development
    • Late Development
  • Digital Walkthrough
☰
  • Home
  • Who we are
  • What we do
    • Early Development
    • Late Development
  • Digital Walkthrough

  • Knowledge Hub
  • News & Events
  • Careers
  • Contact Us
Digital Walkthrough

What we do

Proudly serving global customers, we are your trusted and dependable partner for innovative end-to-end process research and development.

Process Research and Development

We are a scientifically-led, commercially-minded and award-winning innovation partner, dedicated to developing economically and environmentally sustainable pharmaceutical manufacturing processes. We create tailored solutions from candidate selection through clinical development to product launch and beyond, ensuring delivery of your asset to the next step through our in-depth process research and development experience and expertise.

Why choose CatSci?

Our in-depth understanding of process research and development challenges enables us to minimise risks and expedite the progress of your drug development projects in a safer, greener and more cost-effective way. We ensure open consultation and communication in everything we do, to understand you inside out, and proactively address all your concerns and challenges to meet your evolving portfolio needs.

Our highly qualified team of PhD and postdoc scientists has decades of collective experience working on hundreds of drug discovery and development projects for companies of all sizes and from all around the world. This allows us to expertly manage the full complexity of your small molecule projects, working not only as a helping hand but as a true partner for innovation. 

Our ways of working include adopting digital data management tools, which enable us to facilitate knowledge sharing and reduce barriers to efficient ways of working. We ensure total alignment with your internal processes and systems to alleviate any pressures of working with an external partner. Our team takes full responsibility for seamless technology transfer to your in-house manufacturing sites or third-party manufacturing organisations.

We operate a system of Health, Safety and Environmental controls aligned to the rigorous standards set by large pharma to safely and securely deliver all your project demands.

We guarantee complete data and information security to ensure integrity, confidentiality and total protection of your intellectual property rights.

We leverage our partnerships across the wider pharmaceutical value chain and provide important access to the academic excellence that the United Kingdom is renowned for.

Early Development

We have developed hundreds of pre-clinical and Phase I projects successfully. Using a thoroughly consultative approach we take the time to understand your objectives and identify the challenges that you face. The three key areas of early development that we focus on are route scouting and selection, early scale-up, and risk management. We also pride ourselves on utilising the latest advances in science and technology to optimise drug substance manufacturing processes from an early stage.

Learn more
CatSci scientists working in fume hood
Late Development services

Late Development

Our late development work ensures that you are successfully supported through process design and assessment, scale-up for commercial manufacture, tech transfer and post-approval improvements. We can also deliver beyond our in-house non-GMP material supply in a seamless manner by working closely with your preferred manufacturer. Our experienced team has successfully delivered numerous Phase II-III and launch phase projects for Top 50 pharma companies and we continue to deliver to the standards of large pharma.

Learn more

Our Facilities

Our laboratories feature state-of-the-art equipment, including a 10 m glove box for catalysis research, dedicated OEB-4 laboratory and 20 L vessels for non-GMP material supply, along with all requisite analytical and solid state instrumentation. This enables scale-up from milligrams to kilograms in-house, as well as ensuring the necessary technology transfer for GMP manufacturing to expedite project progression. Our range of facilities means we can devise, revise and optimise your chemistry with complete flexibility.

We constantly invest in and expand our bespoke chemistry facilities to broaden our range of laboratory assets. We have dedicated facilities for process understanding and optimisation, catalysis, high pressure reactions, crystallisation, process scale-up, analytical development and non-GMP material supply. We also possess two laboratories for the development of potent compounds (OEB-4). View our Digital Walkthrough to take a 360° virtual tour of our facilities.

Digital Walkthrough

Partnering from pre-clinical
to product launch

PROCESS
EXPERTISE

Rapid routedevelopment & scale-up Green chemistryexploitation Knowledge transferfor first GMP manufacture Route scouting& selection Thermal hazardidentification & mitigation Kilo-scale non-GMP materialsupply (incl. OEB-4)
Process understanding &robustness for manufacturability Sustainability metrics Technology transfer for late-stage& commercial manufacture Process design, development & optimisation Model-led exploration of designspace for process definition Demonstration batches for proof ofconcept & non-clinical development

ANALYTICAL
EXCELLENCE

Method development(In-silico, screening optimisation& qualification) High-throughputreaction profiling Impurity identification& characterisation
Method Robustness studies(AMQBD) Batch analysis(non-GMP) Measurement of trace genotoxic impurities, detailed reaction understanding & data visualisation

MATERIAL
SCIENCE

Enabling solid formscreening & selection Solid-statecharacterisation Formulation manufacturabilityassessment Registered startingmaterial strategy
Comprehensivepolymorph interrogation API control strategy to ensureformulation performance Crystallisationdevelopment & optimisation

CATALYSIS
EXPERIENCE

Medium-throughput & data-richexperimental workflows Reaction screening & catalystselection, incl. high pressurereactions & biocatalysis State-of-the-art expertise inhomogeneous & heterogeneous catalysis,incl. asymmetric hydrogenation
Advanced data science& visualisation techniques Research, development& optimisation ofcatalytic processes Statistical experimentaldesign (DoE, PCA)
CatSci scientist

Who we are

Find out why our team has a proven track record in developing sustainable pharmaceutical manufacturing processes.

CatSci fume hoods

Knowledge Hub

Check out our case studies and other resources on process chemistry, catalysis and more in the Knowledge Hub.

CatSci scientists fume hood

Contact us

Get in touch to find out more or discuss your project objectives.

  • Home
  • Who we are
  • What we do
    • Early Development
    • Late Development
  • Digital Walkthrough
  • Knowledge Hub
  • News & Events
  • Careers
  • Contact Us

Stay in Touch

Sign up
  • Safety, Health & Environment
  • Privacy Policy

© 2011-2020 CatSci Ltd. All rights reserved.
Registered in England & Wales.
Company No. 07466141.

Cookies

This site uses cookies: Find out more.