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January, 2021

Novel Bromination Process slashes PMI

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

January, 2021

Route Redesign to Eliminate Use of PhOCN

The route supplied by the client involved the use of phenyl cyanate for functionalising a heterocyclic intermediate with a nitrile group. Its ongoing use would require cyanide monitoring, a dedicated waste stream treatment step, and there were concerns over the sourcing of material of appropriate quality over the long term.

December, 2020

Development of a Late-Stage Buchwald Amination

CatSci was tasked with the development of a regioselective Buchwald-Hartwig amination for the final bond forming step of an API. The inherited conditions were not robust with respect to reaction conversion leading to stability concerns.

December, 2020

Solubility Data Driven Workup Design & Crystallisation Development

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

December, 2020

Effective Route Scouting allows Pilot Plant Slot to be met

CatSci was tasked with performing route-scouting, route selection and early-phase process development over a 6-month period to meet a pilot plant manufacturing slot.

July, 2020

Solvents In Scale-up Technical Piece – Part II

Solvent Selection Considerations

By: CatSci

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