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Analytical Chemistry Analytical Science Artificial Intelligence (AI) Biocatalysis Catalysis CatSci Paper CatSci Patent Chemical Development Complex Synthetic Medicines Design of Experiments Digital Drug Development Experimental Design Green Chemistry Industry insights Innovation Machine Learning (ML) Material Science Medium Throughput Experimentation Oligonucleotides Peptides Principal Component Analysis Process R&D PROTACs QbD Route Scouting and Selection Scale-up Scavenging Solvents Sustainability Technology transfer Work-up
Early Process Development and Scale-Up of Orally Active Apomorphine Drug Candidates

Org. Process Res. Dev. 2022

2022 By Antonio M. RudaEkaterina Y. MelikhovaJonathan D. MoseleyNadia Fleary-RobertsSiân M. ForsythSimon N. G. TylerSofia PapadouliVargini Thangavadivale, et al.
Application of the Polonovski Reaction: Scale-up of an Efficient and Environmentally Benign ...

Org. Process Res. Dev. 2022, 26, 5, 1398–1404

2022 By Antonio M. RudaSiân M. ForsythSofia PapadouliVargini Thangavadivale, et al.
Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of ...

Org. Process Res. Dev. 2022, 26, 5, 1458–1469

2022 By Antonio M. RudaSiân M. Forsyth, et al.
Mapping the properties of bidentate ligands with calculated descriptors (LKB-bid)

Dalton Trans., 2020, 49, 8169-8178

2020 By Simon N. G. Tyler, et al.
Ketone Reductase Biocatalysis in the Synthesis of Chiral Intermediates Toward Generic Active...

Org. Process Res. Dev. 2020, 24, 6, 1131–1140

2020 By Dan A. SmithJoanne B. SampsonSiân M. Forsyth, et al.
Iron catalysis for the synthesis of ligands: Exploring the products of hydrophosphination as...

Tetrahedron 2017, 73, 64-69

2017 By Simon N. G. Tyler, et al.
An efficient and scalable process to produce morpholine-d₈

Synth. Commun. 2017, 47, 481

2017 By Dan A. Smith, et al.
Concise Xanthine Synthesis through a Double-Amidination Reaction of a 6-Chlorouracil with Am...

ChemSusChem. 2017, 10, 624-628

2016 By Dan A. Smith, et al.
Ligand and solvent selection in challenging catalytic reactions

J. Chem. Technol. Biotechnol. 2014, 89, 623-632

2014 By CatSci team, et al.
Sterically hindered malonamide monomers for the step growth synthesis of polyesters and poly...

Chem. Commun., 2014, 50, 10665-10668

2014 By Simon N. G. Tyler, et al.
Beyond the Numbers: Charting Chemical Reaction Space

Org. Process Res. Dev. 2013, 17, 1, 40–46

2013 By Simon N. G. Tyler, et al.
A mild robust generic protocol for the Suzuki reaction using an air stable catalyst

Tetrahedron 2012, 68, 6010-6017

2012 By Simon N. G. Tyler, et al.

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What we do

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Who we are

CatSci Ltd are an award-winning innovation partner for medicines development who are committed to creating tailored solutions from candidate selection through product launch and beyond. We break down the silos in small molecules, TACS, glues and oligonucleotides CMC development to accelerate the delivery of life-changing medicines to patients in need. 

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