Choosing the Right Technique to Increase Poor Drug Solubility in Solid Oral Dosage Formulations
Whilst good solubility is a target property in many drug discovery programs, a balance is often struck between solubility and potential efficacy which means that a poorly soluble molecule may need to be progressed.
By: Robert Dennehy
Solubility Data Driven Workup Design & Crystallisation Development
CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.