Resources

In this case study, our Bioscience team presents a targeted, efficient screening cascade for CDK4/6 degradation using a commercially available PROTAC®.

Developing oligonucleotide therapeutics demands speed, precision, and seamless collaboration. Our Design–Make–Test–Analyse (DMTA) workflow integrates oligo synthesis and biological testing to deliver faster, data-informed optimisation, turning discovery into delivery.

Our customer’s API was formulated as a cyclodextrin complex to address thermal and oxidative instability. However, filtration at pilot scale was very slow. CatSci’s fully integrated chemistry, material science, formulation and analytical science teams gathered a thorough package of solubility and solution stability data. The process was thoroughly baselined using the Crystal16, the Blaze probe and a lab scale filtration rig. The process was redesigned to improve filtration.