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Scale-up

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Analytical Chemistry Analytical Science Artificial Intelligence (AI) Biocatalysis Catalysis CatSci Paper CatSci Patent Chemical Development Design of Experiments Digital Drug Development Experimental Design Green Chemistry Industry insights Innovation Machine Learning (ML) Material Science Medium Throughput Experimentation Oligonucleotides Principal Component Analysis Process R&D PROTACs QbD Route Scouting and Selection Scale-up Scavenging Solvents Sustainability Technology transfer Work-up
3 CMC Challenges That Can Derail Your Programme

Rob Crook, our Director of Chemical Science, explores the 3 CMC Challenges that can derail your programme's success, along with strategies on how you can overcome scale-up risks, complexity, and speed-vs-strategy pitfalls.

Feb 18th 2025 By Rob Crook
Supporting Early Clinical Supply Through Process Development Excellence

Discover how CatSci rapidly developed a robust and inherently safe process which enabled our customer to support their early clinical supply without surprises or delays.

2023
Deploying AI Enabled Video to Better Understand Crystallisation Events

The CatSci team was set the task of developing a robust scalable manufacturing process suitable for transferring to plant. Discover how they used Lumi, an AI computer vision tool, to monitor and record the reaction, which enabled us to make critical decisions more efficiently and effectively.

2023 By Emmanuelle Juan
Early Process Development and Scale-Up of Orally Active Apomorphine Drug Candidates

Org. Process Res. Dev. 2022

2022 By Antonio M. RudaEkaterina Y. MelikhovaJonathan D. MoseleyNadia Fleary-RobertsSiân M. ForsythSimon N. G. TylerSofia PapadouliVargini Thangavadivale, et al.
Application of the Polonovski Reaction: Scale-up of an Efficient and Environmentally Benign ...

Org. Process Res. Dev. 2022, 26, 5, 1398–1404

2022 By Antonio M. RudaSiân M. ForsythSofia PapadouliVargini Thangavadivale, et al.
Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of ...

Org. Process Res. Dev. 2022, 26, 5, 1458–1469

2022 By Antonio M. RudaSiân M. Forsyth, et al.
Solvents In Scale-up Technical Piece – Part I

General points to consider on solvent selection for scale-up

2021 By CatSci team
Solvents In Scale-up Technical Piece – Part II

Solvent Selection Considerations

2021 By CatSci team
The Small Molecule Manufacturer: Solvents – Making the Green Choice

Dr Alan Steven explains why environmental sustainability and “big picture thinking” should be key considerations when selecting solvents for scale-up.

2021 By Alan Steven
Novel Bromination Process Slashes PMI

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

2021 By Guy BrenchleyDan RichardsJoanne B. SampsonMonica Trues-Suarez
Route Redesign to Eliminate Use of PhOCN

The route supplied by the client involved the use of phenyl cyanate for functionalising a heterocyclic intermediate with a nitrile group. Its ongoing use would require cyanide monitoring, a dedicated waste stream treatment step, and there were concerns over the sourcing of material of appropriate quality over the long term.

2021 By Marc HutchbyFil RotaGareth TuttonNadia Fleary-Roberts
Solubility Data-Driven Workup Design & Crystallisation Development

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

2020 By Dan A. SmithAndrew RobertsAntonio M. RudaNadia Fleary-Roberts
Effective Route Scouting Allows Pilot Plant Slot To Be Met

CatSci was tasked with performing route-scouting, route selection and early-phase process development over a 6-month period to meet a pilot plant manufacturing slot.

2020 By Guy BrenchleyElise RochetteJoanne B. SampsonMarc Hutchby
Development of a Late-Stage Buchwald Amination

CatSci was tasked with the development of a regioselective Buchwald-Hartwig amination for the final bond forming step of an API. The inherited conditions were not robust with respect to reaction conversion leading to stability concerns.

2020 By Siân M. ForsythBeth Rees-HindleyJonathan D. MoseleyJoseph Renny
Process for the preparation of bromodomain inhibitor

WO2020023438

2020 By Antonio M. Ruda, et al.
Ketone Reductase Biocatalysis in the Synthesis of Chiral Intermediates Toward Generic Active...

Org. Process Res. Dev. 2020, 24, 6, 1131–1140

2020 By Dan A. SmithJoanne B. SampsonSiân M. Forsyth, et al.
Physical Parameters In Scale-up Technical Piece

The importance of physical parameters

2020 By CatSci team
The Medicine Maker: Process Development 101: How Not to Burn Down Your Factory

Our article offers tips on how to manufacture your API in the right quantity, at the right cost, and in the right time frame - and not burn your factory down in the process!

2019 By CatSci team
Scale-up Technical Piece

Some scale-up considerations

2019 By CatSci team
Experimental Design Whitepaper

Optimisation of an Acid-mediated Rearrangement with DoE

2018 By CatSci team
Scale-Up Whitepaper

Optimisation of an Asymmetric Hydrogenation

2018 By CatSci team

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What we do

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Who we are

CatSci Ltd are an award-winning innovation partner for medicines development who are committed to creating tailored solutions from candidate selection through product launch and beyond. We break down the silos in small molecules, TACS, glues and oligonucleotides CMC development to accelerate the delivery of life-changing medicines to patients in need. 

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