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Green Chemistry

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Analytical Chemistry Analytical Science Artificial Intelligence (AI) Biocatalysis Catalysis CatSci Paper CatSci Patent Chemical Development Design of Experiments Digital Drug Development Experimental Design Green Chemistry Industry insights Innovation Machine Learning (ML) Material Science Medium Throughput Experimentation Oligonucleotides Principal Component Analysis Process R&D PROTACs QbD Route Scouting and Selection Scale-up Scavenging Solvents Sustainability Technology transfer Work-up
Application of the Polonovski Reaction: Scale-up of an Efficient and Environmentally Benign ...

Org. Process Res. Dev. 2022, 26, 5, 1398–1404

2022 By Antonio M. RudaSiân M. ForsythSofia PapadouliVargini Thangavadivale, et al.
Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of ...

Org. Process Res. Dev. 2022, 26, 5, 1458–1469

2022 By Antonio M. RudaSiân M. Forsyth, et al.
Chemistry Today: Panel Discussion on Catalysis

CatSci's Senior Scientist, Dr Alice Dunbabin, participated in the latest Chemistry Today panel discussion on Catalysis.

2022 By Alice Dunbabin
The Next Decade of Drug Development 

Access the recordings of our 10-year anniversary symposium now. The event was centred on the future of medicines development and featured industry-leading speakers from AstraZeneca, Bristol Myers Squibb, DeepMatter, FogPharma, Merck, Novartis, R.I, Roche, Syngenta, and more.

2021
Pharma Manufacturing: Pharma’s Shift Towards a Circular Economy

Our CCO, Dr Simon Tyler, argues that to achieve true sustainability, a more holistic approach to overall drug development is needed.

2021 By Simon N. G. Tyler
Chemical Development in Pharma 2: A CatSci Virtual Symposium 

Access the recordings of our second virtual symposium now. The event featured an impressive itinerary of three eminent speakers from industry, who delivered digestible 30-minute presentations, covering topics from high throughput experimentation in organic synthesis to separation technology and analytical science.

2021
The Medicine Maker: Are You a Bio-Catalytic Converter?

Speed and efficiency are everything in pharmaceutical synthesis – and that’s why biocatalysis is an increasingly attractive option.

2021 By Alice Dunbabin
Metal Scavenging Whitepaper

Development of a flow scavenging protocol

2021 By CatSci team
The Small Molecule Manufacturer: Solvents – Making the Green Choice

Dr Alan Steven explains why environmental sustainability and “big picture thinking” should be key considerations when selecting solvents for scale-up.

2021 By Alan Steven
Novel Bromination Process Slashes PMI

CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.

2021 By Guy BrenchleyDan RichardsJoanne B. SampsonMonica Trues-Suarez
Route Redesign to Eliminate Use of PhOCN

The route supplied by the client involved the use of phenyl cyanate for functionalising a heterocyclic intermediate with a nitrile group. Its ongoing use would require cyanide monitoring, a dedicated waste stream treatment step, and there were concerns over the sourcing of material of appropriate quality over the long term.

2021 By Marc HutchbyFil RotaGareth TuttonNadia Fleary-Roberts
Designing a Robust Scalable Catalytic Process

The client's Phase 1 process was struggling to deliver API in low kg qualities. In particular, Intermediate B was of variable quality, and residual metals were known to negatively affect the onward chemistry.

2020 By Vargini ThangavadivaleDan A. SmithSiân M. Forsyth
Effective Route Scouting Allows Pilot Plant Slot To Be Met

CatSci was tasked with performing route-scouting, route selection and early-phase process development over a 6-month period to meet a pilot plant manufacturing slot.

2020 By Guy BrenchleyElise RochetteJoanne B. SampsonMarc Hutchby
Development of a Late-Stage Buchwald Amination

CatSci was tasked with the development of a regioselective Buchwald-Hartwig amination for the final bond forming step of an API. The inherited conditions were not robust with respect to reaction conversion leading to stability concerns.

2020 By Siân M. ForsythBeth Rees-HindleyJonathan D. MoseleyJoseph Renny
Faster, Cleaner and Greener: Why chemistry in micellar and micellar-like media is now a viab...

CatSci's Senior Principal Scientist, Dr Alan Steven presented a free webinar organised by Scientific Update, entitled ‘Faster, Cleaner and Greener: Why chemistry in micellar and micellar-like media is now a viable option for chemical development and beyond’.

2020
The Medicine Maker: From Big Pharma to New Green Horizons: Lessons Learned with Ross Burn

Our CEO, Dr Ross Burn talks about surviving and thriving as a new company focused on process chemistry, alongside more recent moves into industry 4.0 and collaborations in the contract research space.

2020 By Ross T. Burn
Chemical Development in Pharma: A CatSci Virtual Symposium

Access the recordings of our first virtual symposium now. The event featured an impressive itinerary of four eminent speakers spanning industry and academia, who delivered digestible 30-minute presentations, covering topics from green technologies to material science, such as crystallisation.

2020
Process for the preparation of bromodomain inhibitor

WO2020023438

2020 By Antonio M. Ruda, et al.
Selective Catalytic Synthesis of 1,2- and 8,9-Cyclic Limonene Carbonates as Versatile Buildi...

Chem. Eur. J., 2020, 26, 1–12

2020 By Marc Hutchby, et al.
Green Chemistry Articles of Interest to the Pharmaceutical Industry

Org. Process Res. Dev. 2020, 24, 6, 897–908

2020 By Alan Steven, et al.
Mapping the properties of bidentate ligands with calculated descriptors (LKB-bid)

Dalton Trans., 2020, 49, 8169-8178

2020 By Simon N. G. Tyler, et al.
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What we do

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Who we are

CatSci Ltd are an award-winning innovation partner for medicines development who are committed to creating tailored solutions from candidate selection through product launch and beyond. We break down the silos in small molecules, TACS, glues and oligonucleotides CMC development to accelerate the delivery of life-changing medicines to patients in need. 

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