Catalysis Archives

Metal Control Strategy in Drug Development: The Importance of Getting It Right

Our Director of Analytical Science, Sam Whitmarsh, and our Director of Chemical Science, Rob Crook describe CatSci's robust metal control strategies and workflows that ensure alignment with the ICHQ3D requirements and ultimately patient safety.

Application of the Polonovski Reaction: Scale-up of an Efficient and Environmentally Benign ...

Org. Process Res. Dev. 2022, 26, 5, 1398–1404

Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of ...

Org. Process Res. Dev. 2022, 26, 5, 1458–1469

Chemistry Today: Panel Discussion on Catalysis

CatSci's Senior Scientist, Dr Alice Dunbabin, participated in the latest Chemistry Today panel discussion on Catalysis.

The Next Decade of Drug Development

Access the recordings of our 10-year anniversary symposium now. The event was centred on the future of medicines development and featured industry-leading speakers from AstraZeneca, Bristol Myers Squibb, DeepMatter, FogPharma, Merck, Novartis, R.I, Roche, Syngenta, and more.

Faster, Cleaner and Greener: An Introduction to Micellar Catalysis for Medicine Development

Find out more about micellar catalysis, including its environmental, economic and productivity benefits.

The Medicine Maker: Are You a Bio-Catalytic Converter?

Speed and efficiency are everything in pharmaceutical synthesis – and that’s why biocatalysis is an increasingly attractive option.

Method Development for High Throughput Sample Analysis

CatSci was tasked with catalyst screening for an asymmetrical hydrogenation of a target.

Metal Scavenging Whitepaper

Development of a flow scavenging protocol

The Small Molecule Manufacturer: Solvents – Making the Green Choice

Dr Alan Steven explains why environmental sustainability and “big picture thinking” should be key considerations when selecting solvents for scale-up.

Designing a Robust Scalable Catalytic Process

The client's Phase 1 process was struggling to deliver API in low kg qualities. In particular, Intermediate B was of variable quality, and residual metals were known to negatively affect the onward chemistry.

Development of a Late-Stage Buchwald Amination

CatSci was tasked with the development of a regioselective Buchwald-Hartwig amination for the final bond forming step of an API. The inherited conditions were not robust with respect to reaction conversion leading to stability concerns.