How expert route scouting and selection could save you time, money, and environmental impact.
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Analytical Chemistry
Analytical Science
Artificial Intelligence (AI)
Biocatalysis
Catalysis
CatSci Paper
CatSci Patent
Chemical Development
Design of Experiments
Digital
Drug Development
Experimental Design
Green Chemistry
Industry insights
Innovation
Machine Learning (ML)
Material Science
Medium Throughput Experimentation
Oligonucleotides
Principal Component Analysis
Process R&D
PROTACs
QbD
Route Scouting and Selection
Scale-up
Scavenging
Solvents
Sustainability
Technology transfer
Work-up
This whitepaper explores how CatSci’s bespoke route scouting and process development strategies were harnessed on a time-sensitive proteolysis targeting chimera (PROTAC®) programme.
Discover our industry-leading route selection process and assessment tools.
Discover how CatSci rapidly developed a robust and inherently safe process which enabled our customer to support their early clinical supply without surprises or delays.
General points to consider on solvent selection for scale-up
Understanding their common decomposition pathways
Solvent Selection Considerations
Development of a flow scavenging protocol
The importance of physical parameters
Some scale-up considerations
A general approach to the optimisation of Buchwald-Hartwig aminations for organic chemists
Phase-dependent process R&D
Development of a DKR for the manufacture of (S)-Flurbiprofen
Optimisation of an Acid-mediated Rearrangement with DoE
Why Biocatalysis?
Optimisation of an Asymmetric Hydrogenation
Design of a Washing Regime to Purge a Regioisomer