December, 2020
How to make sure salt screens are as effective as possible
By: Robert Dennehy
Watch the full panel discussion, including insights from CatSci CEO Ross Burn, from the Pharma Integrates virtual event in November 2020.
By: Ross Burn
CatSci was tasked with the development of a regioselective Buchwald-Hartwig amination for the final bond forming step of an API. The inherited conditions were not robust with respect to reaction conversion leading to stability concerns.
The client's Phase 1 process was struggling to deliver API in low kg qualities. In particular, Intermediate B was of variable quality, and residual metals were known to negatively affect the onward chemistry
CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.
CatSci was tasked with performing route-scouting, route selection and early-phase process development over a 6-month period to meet a pilot plant manufacturing slot.
