February, 2021 , The Medicine Maker
Speed and efficiency are everything in pharmaceutical synthesis – and that’s why biocatalysis is an increasingly attractive option
By: Alice Dunbabin
January, 2021 , The Small Molecule Manufacturer
Alan Steven explains why environmental sustainability and “big picture thinking” should be key considerations when selecting solvents for scale-up
By: Alan Steven
January, 2021
CatSci was tasked with catalyst screening for an asymmetrical hydrogenation of a target.
By: CatSci
Development of a flow scavenging protocol
CatSci was tasked with designing a new bromination method for a key reaction intermediate. Use of bromine rendered the previous process unsuitable for a larger campaign and would require expensive and time-consuming alterations to the plant.
The route supplied by the client involved the use of phenyl cyanate for functionalising a heterocyclic intermediate with a nitrile group. Its ongoing use would require cyanide monitoring, a dedicated waste stream treatment step, and there were concerns over the sourcing of material of appropriate quality over the long term.
