|
Key Equipment Type |
Brand |
Comment |
| Process R&D – Standard |
Amigo reactor |
Amigochem |
Sampling and dilution of materials taken from the Integrity 10 reactor |
| Antistatic kit universal |
Mettler Toledo |
To assist with the weighing of static materials |
| 250 mL-5L jacketed vessels |
Radleys |
|
| 20L jacketed vessels |
Labtex |
Used to produce specimen scale-up batches up to around 1 kg |
| EasySampler |
Mettler-Toledo |
Automated sampling and reaction profile monitoring, including air sensitive reactions. |
| 250mL-5L filtration equipment |
|
Used for large scale filtrations under positive or negative pressure, with heat jacket and overhead stirring |
| Huber Unistat 360 |
Huber |
Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C |
| Huber Unistat 430 |
Huber |
Used for heating and cooling reactors between 5 and 20 L from -40 °C to +250 °C |
| Huber Ministat 230 |
Huber |
Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C |
| Heidolph Distimatic |
Heidolph |
Automated distillation & concentration of solvents, from 500 mL to > 20 L. Fully automated system, used mostly for large-scale processes |
| Chemicalize |
ChemAxon |
pKa, logP and 1H NMR predictions |
| Mya 4 Reaction Station |
Radleys |
A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. |
| SP-50 dosing unit |
Mettler Toledo |
Adding solutions to a vessel with feedback control to other peripherals |
| Hot stage microscope |
Zeiss |
High resolution assessment of crystallinity, particle shape and size |
| Integrity 10 |
|
Allows 10 tube-scale reactions to be performed in parallel with independent control of stirirng and heating |
| JMP 12 |
JMP |
Statistical data analysis software |
| pH meter |
Hanna |
|
| Centrifuge |
Hettich |
|
| Cold plate |
|
Maintaining a constant subambient temperature for chemistry performed in vials |
| Crystal 16 |
Technobis |
Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL |
| DSC |
Mettler Toledo |
Thermal and thermodynamic stability of materials with autosampler |
| Distimatic |
Heidolph |
Automated distillation unit |
| ELN |
Revvity Signals |
Electronic lab notebook |
| EquaVAP Evaporator |
EquaVAP |
Used to evaporate solvent from vials in plates |
| Isolera |
Biotage |
Automated flash system |
| Karl Fischer coulometry |
Metrohm |
Detection of water content of samples |
| Labgear |
|
Lab automation software |
| Melting point apparatus |
|
Establishing the melting point of solids |
| Microscope Axioscope 5 |
Zeiss |
High resolution assessment of crystallinity, particle shape and size |
| MestreNova |
Mestrelab |
A suite of software to process analytical chemistry data |
| Polar Bear Plus |
Cambridge Reactor Design |
A heating and cooling plate that stirs and heats and cools from -40 °C to 150 °C. |
| RX10 units |
Mettler Toledo |
RX-10 chemical reactor control system that automates jacketed laboratory reactors to ensure excellent reaction control and data-rich experimentation |
| Seven Excellence pH meter |
Mettler Toledo |
A multi-channel benchtop pH meter for precise measurements of pH, conductivity, dissolved oxygen, and ion concentration |
| TGA |
Mettler Toledo |
Measuring levels of loosely bound solvent |
| TSu |
HEL |
Fast screening of thermal and pressure hazards |
| VacMaster filtration unit |
Biotage |
Assessment of the filtration performance of parallel samples. |
| Zotero |
Zotero |
Reference management system |
| Vapourtec R series |
Vapourtec |
Flow reactor, pump, UV-150 photoreactor and autosampler |
| DynoChem |
Mettler Toledo |
Modelling software to enhance process understanding and develop scalable, robust unit operations quickly with reduced experimentation |
| Process R&D – OEB-5 |
EasyMax |
Mettler Toledo |
A 2-zone reaction station offering safe and precise heating, active cooling, software control and remote data-logging for 24/7 unattended chemistry. |
| Greenhouse evaporator |
Radleys |
Low footprint concentration of high hazard solutions within an isolator environment |
| VChamber |
MeltPrep |
Low footprint drying of high hazard solids within an isolator environment |
| Isolator |
CTS |
Handling of compounds with OEL’s less than 0.03 µg/m3. |
| Process R&D – OEB-4 |
Controlled Substances Box |
|
Used for keeping highly potent, pharmacologically active controlled substances. Keyholders strictly controlled & registered with Home Office; contents routinely audited to ensure compliance |
| Selekt and ELSD |
Biotage |
Automated flash system. ELSD allows the detection of analytes without a chromophore. |
| Huber Minichiller 600 |
Huber |
Used for cooling and heating condensers at lab scale reactions (-20 °C to +40 °C). Part of our green chemistry initiative, reducing waste water (estimated to save at least 100 L per hour for each system) as coolant is recirculated |
| Huber CC-505 |
Huber |
Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C |
| Huber Ministat 230 |
Huber |
Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C |
| EasyMax 102 |
Mettler Toledo |
Enables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction. |
| Radley Reactor-Ready |
Radley |
Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
| Mya 4 Reaction Station |
Radley |
A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. |
| EasyMax 102 (including Optimax HFCal) |
Mettler-Toledo |
Enables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction, potential risks and by-products, and is connected to a gas flow meter |
| ECB Box |
Mettler-Toledo |
Connects EasyMax to 3rd party sensors |
| Nutsche filter dryer |
Bachiller |
Enables in situe drying of filtered material, reducing the handling steps in a potent environment. Agitation also allows for in-situ slurry washing of the filter cake, allowing for better reporoduction of certain manufacturing scale capabilities |
| Tsu |
H.E.L group |
Used to screen different pressures and temperatures of a sample on the same platform |
| Filter dryer |
Powder Systems |
Isolation of highly potent materials |
| Hydrogen generator |
H-Genie |
Supply of up to 100 bar pressure of hydrogen |
| Isolator |
CTS |
Containment of highly potent materials |
| Agilent 1100 x 2 |
Agilent |
Walk up LC-MS, coupled to ZQ Mass Spec |
| Catalysis |
Glove box |
Mbraun |
10 m3 Glovebox maintained at < 10 ppm O2, used for catalyst screening and sensitive reactions. Equipped with twin purifier system and 30 gloves. |
| Biotage Endeavour |
Biotage |
Used for parallel, multi-reactor optimisation of pressurised reactions (8 x 1-4 mL tubes, up to 30 bar pressure and 200°C) |
| HEL Cat-96 |
H.E.L group |
Used for high throughput catalyst screening in 96 well plates (96 x 200-1000 uL vials, up to 34 bar and 200 °C). Also available is the HEL Cat-7, used for parallel catalyst screening (7 x 3-20 mL tubes, up to 100 bar and 200 °C) |
| 1L Buchi autoclave |
Buchi |
Allows for pressurised reactions up to 1L at 10 bar |
| Miniclave Drive (300 mL) |
Buchi |
A multipurpose steel pressure reactor system designed for use with interchangeable steel pressure vessels. |
| Pressflow controller |
Buchi |
System used to quantify the delivery of gasses |
| Cat 7 |
HEL |
7 position reactor for manual catalyst screening |
| Cat 96 |
HEL |
96 position reactor for manual catalyst screening |
| Genevac EZ-2 |
Biopharma Group |
centrifugal solvent evaporator system |
| LED aquarium lamp and controller |
Kessil |
Photoredox reactions enabled by blue light |
| Man on the Moon |
manonthemoontech.com |
Monitoring hydrogen uptake in small scale hydrogenation reactions |
| Tumble stirrer |
|
Agitation of biotransformations |
| Parr hydrogenator |
Parr Instrument Company |
Used for high pressure reactions, handling volumes up to 600 mL |
| Analytical Science |
Metrohm KF Ti-Touch and Metrohm KF Titrino |
Metrohm |
Water determination by KF |
| Metrohm Coulometric KF and Thermoprep oven |
Metrohm |
Water determination by KF (samples unamenable to direct KF titration) |
| Fusion |
S-Matrix |
AI method development |
| Powder weighing cabinet x 2 |
Safetech |
Safety weighing enclosure for solids/liquids, to protect up to OEB4 (1-10ug/m3), containing 6 figure analytical balance |
| Agilent 1100/1200 HPLC x 4 |
Agilent |
Used for process development. 1 x equipped with quaternary pump and Variable Wavelength Detector (VWD), used for chiral analysis. |
| Agilent 1100/1200 HPLC-MS |
Agilent |
Equipped with ZQ mass spectrometer. Used for process development and optimisation |
| Agilent 1220 HPLC x 2 |
Agilent |
Equipped with DAD/VWD. Used for general project support. |
| Agilent 1220 HPLC-CAD |
Agilent |
DAD with Charged Aerosol Detector (CAD) for analysis of compounds with poor chromophores |
| Agilent 1260 HPLC x 3 |
Agilent |
Equipped with DAD/VWD. 1 x equipped with column switcher. Used for method development and project support |
| Agilent 1260 HPLC x 2 |
Agilent |
Equipped with DAD and Masshunter open-access interface, for general project support |
| Agilent 1260 HPLC-MS |
Agilent |
Equipped with 6150 mass spectrometer. Used for process development and optimisation |
| Agilent 1290 UPLC |
Agilent |
Used for method development and optimisation |
| Agilent 1290 UPLC x 2 |
Agilent |
1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission |
| Agilent 1290 UPLC-MS x 2 |
Agilent |
1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission. iQ mass detector allows for process optimisation |
| Agilent 6550LC/Q-TQF MS |
Agilent |
High Resolution Accurate Mass MS/MS instrument for Compound ID, analysis of large molecules (Oligos, Peptides, etc), trace analysis (GI’s and Nitrosamines) and complex mixture analysis |
| Agilent 6550 iFunnel Q-Tof LC/MS |
Agilent |
High Resolution Accurate Mass MS/MS instrument for Compound ID, analysis of large molecules (Oligos, Peptides, etc), trace analysis (GI’s and Nitrosamines) and complex mixture analysis |
| Waters ACQUITY I-Class UPLC-MS |
Waters |
Equipped with Triple Quadrupole Detector (TQD) and 4 column manager, used for rapid method screening, with open access software |
| Waters ACQUITY H-Class UPLC-MS |
Waters |
Equipped with QDa mass detector, 4 column switcher with open access software |
| Shimadzu LC20/30 HPLC |
Shimadzu |
Equipped with 6 way column switcher for rapid reverse-phase chiral screening system |
| Thermo Vanquish Duo UPLC-CAD-MS x 2 |
Thermo |
Equipped with CAD and DAD and dual pumps for reverse gradient. Applied to the quantification of compounds and impurities with poor chromophores |
| Agilent 7890B GC-FID |
Agilent |
Equipped with dual Flame Ionisation Detector (FID) and dual injector |
| Agilent 6890N GC-FID |
Agilent |
Equipped with dual Flame Ionisation Detector (FID), headspace sample injector |
| Agilent 8890 GC-FID-MS |
Agilent |
Equipped with a single-quadropole MS for impurity identification |
| Agilent 8890 FID-VUV |
Agilent/VUV |
Equipped with Flame ionisation Detector and Vacuum UV detector to allow analysis of trace levels including moisture, and solvents in a single analytical method |
| Shimadzu i-series 2050 x 2 |
Shimadzu |
Used for routine sample analysis (integrated with LabSolutions DCS) |
| Shimadzu XS UPLC |
Shimadzu |
Used for rapid method screening and method optimisation |
| Shimadzu LC40 LC-MS 2020 |
Shimadzu |
Impurity identification (integrated with LabSolutions DCS) |
| Shimadzu GC-MS 2020NX |
Shimadzu |
Also has FID detector. Impurity identification (integrated with LabSolutions DCS) |
| Shimadzu GC OAC6000 |
Shimadzu |
GC-FID system for routine sample analysis (integrated with LabSolutions DCS) |
| Labsolutions |
Shimadzu |
Used for GMP chromatography data system |
| Labware |
Labware |
Used for GMP LIMS/ELN |
| Thermal Screening Unit |
HEL |
For identifying thermal and pressure hazards in reaction mixes and raw material liquids and powders |
| JEOL 400MHz NMR |
Jeol |
Equipped with 30 place autosampler – Used for in-house process development, confirmation of structure and assay |
| ICP-MS |
Shimadzu |
Residual metals analysis and ICHQ3D |
| Agilent 1290 UPLC-QTOF |
Agilent |
Equipped with MS/MS capability, with a high-resolution TOF stage with, ability to analyse larger molecular weight compounds such as oligonucleotides |
| Shimadzu Tm-UV |
Shimadzu |
UV instrument with temperature modifying capability to enable analysis of oligonucleotides |
| Crystallisation, Solid State and Preformulation |
Parallel Crystalliser – Crystal 16 |
Technobis |
Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL |
| Crystalline |
Technobis |
Crystallisation process design up to 8 mL with overhead stirring |
| FTIR |
Shimadzu |
Used to confirm the identity of a material and to differentiate between polymorphs |
| DSC |
Mettler Toledo |
Thermal and thermodynamic stability of materials with autosampler |
| EquaVAP Evaporator |
EquaVAP |
Used to evaporate solvent from vials in plates |
| XRPD |
Malvern Panalytical |
Identification of solid state forms |
| VacMaster Filtration Unit |
Biotage |
Used to assess filtrations before scale-up |
| TGA |
Mettler Toledo |
Levels of loosely bound solvent |
| Hot Stage Microscope |
Leica |
Assessment of crystallinity, particle shape and size, and polymorph change at varying temperatures |
| Microscope |
Zeiss |
High resolution assessment of crystallinity, particle shape and size |
| Lab scale fluid energy mill |
FPS |
Used to control the size of seed used in crystallisation studies |
| Tapped bulk density |
Anton-Paar |
Used to assess flowability of powders handled |
| Malvern 3000 particle sizer |
Malvern Panalytical |
Particle size measurements |
| Stability chambers |
Camlab |
Investigational stability of drug substance and drug product |
| Stability oven |
Memmert |
Used to evaluate the stability of API over time under controlled temperature, humidity and light environments |
| Blaze 900 probe |
Blaze |
Used for in-process particle characterisation by imaging and chord length distribution analysis |
| Radley Reactor-Ready |
Radley |
Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
| microDISS Profiler |
Pion |
Used to measure the dissolution profiles of API in physilogic media |
| DVS Intrinsic Plus |
Surface Measurement Systems Ltd. |
Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid |
| Mya 4 Reaction Station |
Radley |
A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. |
| Oligonucleotides PR&D |
MerMade 12 Oligonucleotide Synthesiser |
LGC |
50 nmol to 200 µmol synthesis scale. Medium throughput synthesier with a 12 column configuration and 20 amidite positions. |
| ÄKTA OligoSynt™ |
Cytiva |
10 µmol to 12 mmol synthesis scale. Compact, fully automated oligonucleotide synthesizer with broad scale for robust and scalable process development and transfer to manufacturing |
| Oligonucleotides Analytical |
Agilent 1290 Infinity II UPLC |
Agilent |
|
| Agilent 1290 Infinity II Prep-LC |
Agilent |
|
| Agilent AdvanceBio 6545XT QToF w/ BioConfirm |
Agilent |
|
| ThermoFisher NanoDrop One-C |
ThermoFisher |
|
