| Process R&D – Standard | 20L jacketed vessels | Diehm | Used to produce specimen scale-up batches up to around 1 kg |
| EasySampler | Mettler-Toledo | Automated sampling and reaction profile monitoring, including air sensitive reactions |
| 5L filtration equipment | | Used for large scale filtrations under positive or negative pressure, with heat jacket and overhead stirring |
| Huber Unistat 360 | Huber | Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C |
| Huber Unistat 430 | Huber | Used for heating and cooling reactors between 5 and 20 L from -40 °C to +250 °C |
| Huber Ministat 230 | Huber | Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C |
| Biotage microwave reactor | Biotage | Used for microwave reaction screenings, from 2.5 to 5mL, up to 20 bar and temperature range of 60 °C to 250 °C with automated sample processing |
| Freeze dryer | SP Scientific | Used to remove water from samples at sub zero temperature |
| Heidolph Distimatic | Heidolph | Automated distillation & concentration of solvents, from 500 mL to > 20 L. Fully automated system, used mostly for large-scale processes |
| Synthia | Merck Millipore | Automated retrosynthesis |
| Chemicalize | ChemAxon | pKa, logP and1H NMR predictions |
| DynoChem | Scale-up Systems | Modelling software to enhance process understanding and develop scalable, robust unit operations quickly with reduced experimentation |
| Process R&D – OEB-5 | EasyMax | Mettler Toledo | A 2-zone reaction station offering safe and precise heating, active cooling, software control and remote data-logging for 24/7 unattended chemistry. |
| Greenhouse evaporator | Radleys | Low footprint concentration of high hazard solutions within an isolator environment |
| VChamber | MeltPrep | Low footprint drying of high hazard solids within an isolator environment |
| Isolator | CTS | Handling of compounds with OEL’s less than 0.03 µg/m3. |
| Process R&D – OEB-4 | Controlled Substances Box | Biotage | Used for keeping highly potent, pharmacologically active controlled substances. Keyholders strictly controlled & registered with Home Office; contents routinely audited to ensure compliance |
| Flash Purification System | Huber | Biotage Isolera One Automated flash system |
| Huber Minichiller 600 | Huber | Used for cooling and heating condensers at lab scale reactions (-20 °C to +40 °C). Part of our green chemistry initiative, reducing waste water (estimated to save at least 100 L per hour for each system) as coolant is recirculated |
| Huber CC-505 | | Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C |
| Huber Ministat 230 | Huber | Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C |
| Radley Reactor-Ready | Radley | Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
| Mya 4 Reaction Station | Radley | A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. |
| EasyMax 102 (including Optimax HFCal) | Mettler-Toledo | Enables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction, potential risks and by-products, and is connected to a gas flow meter |
| ECB Box | Mettler-Toledo | Connects EasyMax to 3rd party sensors |
| Nutsche filter dryer | Bachiller | Enables in situe drying of filtered material, reducing the handling steps in a potent environment. Agitation also allows for in-situ slurry washing of the filter cake, allowing for better reporoduction of certain manufacturing scale capabilities |
| Tsu | H.E.L group | Used to screen different pressures and temperatures of a sample on the same platform |
| Filter dryer | Powder Systems | Isolation of highly potent materials |
| Agilent 1100 x 2 | Agilent | Walk up LC-MS, coupled to ZQ Mass Spec |
| Catalysis | Glove box | Mbraun | 10 m3 Glovebox maintained at < 10 ppm O2, used for catalyst screening and sensitive reactions. Equipped with twin purifier system and 30 gloves |
| Biotage Endeavour | Biotage | Used for parallel, multi-reactor optimisation of pressurised reactions (8 x 1-4 mL tubes, up to 30 bar pressure and 200°C) |
| HEL Cat-96 | H.E.L group | Used for high throughput catalyst screening in 96 well plates (96 x 200-1000 uL vials, up to 34 bar and 200 °C). Also available is the HEL Cat-7, used for parallel catalyst screening (7 x 3-20 mL tubes, up to 100 bar and 200 °C) |
| 1L Buchi autoclave | Buchi | Allows for pressurised reactions up to 1L at 10 bar |
| Parr hydrogenator | Parr Instrument Company | Used for high pressure reactions, handling volumes up to 600 mL |
| Analytical Science | Metrohm KF Ti-Touch and Metrohm KF Titrino | Metrohm | Water determination by KF |
| Metrohm Coulometric KF and Thermoprep oven | Metrohm | Water determination by KF (samples unamenable to direct KF titration) |
| Percepta | ACD | In silico method development |
| Powder weighing cabinet x 2 | Safetech | Safety weighing enclosure for solids/liquids, to protect up to OEB4 (1-10ug/m3), containing 6 figure analytical balance |
| Agilent 1100/1200 HPLC x 4 | Agilent | Used for process development. 1 x equipped with quaternary pump and Variable Wavelength Detector (VWD), used for chiral analysis. |
| Agilent 1100/1200 HPLC-MS | Agilent | Equipped with ZQ mass spectrometer. Used for process development and optimisation |
| Agilent 1220 HPLC x 2 | Agilent | Equipped with DAD/VWD. Used for general project support. |
| Agilent 1220 HPLC-CAD | Agilent | DAD with Charged Aerosol Detector (CAD) for analysis of compounds with poor chromophores |
| Agilent 1260 HPLC x 3 | Agilent | Equipped with DAD/VWD. 1 x equipped with column switcher. Used for method development and project support |
| Agilent 1260 HPLC x 2 | Agilent | Equipped with DAD and Masshunter open-access interface, for general project support |
| Agilent 1260 HPLC-MS | Agilent | Equipped with 6150 mass spectrometer. Used for process development and optimisation |
| Agilent 1290 UPLC | Agilent | Used for method development and optimisation |
| Agilent 1290 UPLC x 2 | Agilent | 1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission |
| Agilent 1290 UPLC-MS x 2 | Agilent | 1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission. iQ mass detector allows for process optimisation |
| Waters ACQUITY I-Class UPLC-MS | Waters | Equipped with Triple Quadrupole Detector (TQD) and 4 column manager, used for rapid method screening, with open access software |
| Waters ACQUITY H-Class UPLC-MS | Waters | Equipped with QDa mass detector, 4 column switcher with open access software |
| Shimadzu LC20/30 HPLC | Shimadzu | Equipped with 6 way column switcher for rapid reverse-phase chiral screening system |
| Thermo Vanquish Duo UPLC-CAD-MS | Thermo | Equipped with CAD, MS and reverse gradient for ID and quantification of compounds and impurities with poor chromophores |
| Agilent 7890B GC-FID | Agilent | Equipped with dual Flame Ionisation Detector (FID) and dual injector |
| Agilent 6890N GC-FID | Agilent | Equipped with dual Flame Ionisation Detector (FID), headspace sample injector |
| Agilent 8890 GC-FID-MS | Agilent | Equipped with a single-quadropole MS for impurity identification |
| Shimadzu i-series 2050 x 2 | Shimadzu | Used for routine sample analysis (integrated with LabSolutions DCS) |
| Shimadzu XS UPLC | Shimadzu | Used for rapid method screening and method optimisation |
| Shimadzu LC40 LC-MS 2020 | Shimadzu | Impurity identification (integrated with LabSolutions DCS) |
| Shimadzu GC-MS 2020NX | Shimadzu | Also has FID detector. Impurity identification (integrated with LabSolutions DCS) |
| Shimadzu GC OAC6000 | Shimadzu | GC-FID system for routine sample analysis (integrated with LabSolutions DCS) |
| Labsolutions | Shimadzu | Used for GMP chromatography data system |
| Labware | Labware | Used for GMP LIMS/ELN |
| Thermal Screening Unit | HEL | For identifying thermal and pressure hazards in reaction mixes and raw material liquids and powders |
| JEOL 400MHz NMR | Jeol | Equipped with 30 place autosampler – Used for in-house process development, confirmation of structure and assay |
| ICP-MS | Shimadzu | Residual metals analysis and ICHQ3D |
| Crystallisation, Solid State and Preformulation | Parallel Crystalliser – Crystal 16 | Technobis | Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL |
| Crystalline | Technobis | Crystallisation process design up to 8 mL with overhead stirring |
| FTIR | Shimadzu | Used to confirm the identity of a material and to differentiate between polymorphs |
| DSC | Mettler Toledo | Thermal and thermodynamic stability of materials with autosampler |
| EquaVAP Evaporator | EquaVAP | Used to evaporate solvent from vials in plates |
| XRPD | Malvern Panalytical | Identification of solid state forms |
| VacMaster Filtration Unit | Biotage | Used to assess filtrations before scale-up |
| TGA | Mettler Toledo | Levels of loosely bound solvent |
| Microscope | Leica | High resolution assessment of crystallinity, particle shape and size |
| Microscope | Zeiss | Assessment of crystallinity and particle shape, and futureproofed for hot stage work |
| Lab scale fluid energy mill | FPS | Used to control the size of seed used in crystallisation studies |
| Tapped bulk density | Anton-Paar | Used to assess flowability of powders handled |
| Malvern 3000 particle sizer | Malvern Panalytical | Particle size measurements |
| Stability chambers | Camlab | Investigational stability of drug substance and drug product |
| Stability oven | Memmert | Used to evaluate the stability of API over time under controlled temperature, humidity and light environments |
| Blaze 900 probe | Blaze | Used for in-process particle characterisation by imaging and chord length distribution analysis |
| Radley Reactor-Ready | Radley | Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
| microDISS Profiler | Pion | Used to measure the dissolution profiles of API in physilogic media |
| DVS Intrinsic Plus | Surface Measurement Systems Ltd. | Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid |
| Mya 4 Reaction Station | Radley | A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry |
