Our Equipment

 Key Equipment TypeBrandComment
Process R&D – StandardAmigo reactorAmigochemSampling  and dilution of materials taken from the Integrity 10 reactor
250 mL-5L jacketed vesselsvessels
Radleys
To assist with the weighing of static materials
20L jacketed vessels LabtexUsed to produce specimen scale-up batches up to around 1 kg
EasySamplerMettler-ToledoAutomated sampling and reaction profile monitoring, including air sensitive reactions.
250mL-5L filtration equipmentUsed for large scale filtrations under positive or negative pressure, with heat jacket and overhead stirring
Huber Unistat 360HuberUsed for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C
Huber Unistat 430HuberUsed for heating and cooling reactors between 5 and 20 L from -40 °C to +250 °C
Huber Ministat 230HuberUsed for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C
Heidolph DistimaticHeidolphAutomated distillation & concentration of solvents, from 500 mL to > 20 L. Fully automated system, used mostly for large-scale processes
ChemicalizeChemAxonpKa, logP and 1H NMR predictions
Mya 4 Reaction StationRadleysA 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry.
SP-50 dosing unitMettler ToledoAdding solutions to a vessel with feedback control to other peripherals
Hot stage microscopeZeissHigh resolution assessment of crystallinity, particle shape and size
Integrity 10Allows 10 tube-scale reactions to be performed in parallel with independent control of stirirng and heating
JMP 12JMPStatistical data analysis software
pH meterHanna
CentrifugeHettich
Cold plateMaintaining a constant subambient temperature for chemistry performed in vials
Crystal 16TechnobisUsed to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL
DSCMettler ToledoThermal and thermodynamic stability of materials with autosampler
DistimaticHeidolphAutomated distillation unit
ELNRevvity SignalsElectronic lab notebook
EquaVAP EvaporatorEquaVAP
Used to evaporate solvent from vials in plates
IsoleraBiotageAutomated flash system
Karl Fischer coulometryMetrohmDetection of water content of samples
LabgearLab automation software
Melting point apparatusEstablishing the melting point of solids
Microscope Axioscope 5Zeiss
High resolution assessment of crystallinity, particle shape and size
MestreNovaMestrelabA suite of software to process analytical chemistry data
Polar Bear PlusCambridge Reactor DesignA heating and cooling plate that stirs and heats and cools from -40 °C to 150 °C.
RX10 unitsMettler ToledoRX-10 chemical reactor control system that automates jacketed laboratory reactors to ensure excellent reaction control and data-rich experimentation
Seven Excellence pH meterMettler ToledoA multi-channel benchtop pH meter for precise measurements of pH, conductivity, dissolved oxygen, and ion concentration
TGAMettler ToledoMeasuring levels of loosely bound solvent
TSuHELFast screening of thermal and pressure hazards
VacMaster filtration unitBiotageAssessment of the filtration performance of parallel samples.
ZoteroZotero
Reference management system
Vapourtec R seriesVapourtecFlow reactor, pump, UV-150 photoreactor and autosampler
DynoChemMettler ToledoModelling software to enhance process understanding and develop scalable, robust unit operations quickly with reduced experimentation
Process R&D – OEB-5EasyMaxMettler ToledoA 2-zone reaction station offering safe and precise heating, active cooling, software control and remote data-logging for 24/7 unattended chemistry.
Greenhouse evaporatorRadleysLow footprint concentration of high hazard solutions within an isolator environment
VChamberMeltPrepLow footprint drying of high hazard solids within an isolator environment
IsolatorCTSHandling of compounds with OEL’s less than 0.03 µg/m3.
Process R&D – OEB-4Controlled Substances Box 
Used for keeping highly potent, pharmacologically active controlled substances. Keyholders strictly controlled & registered with Home Office; contents routinely audited to ensure compliance
Selekt and ELSDBiotageAutomated flash system.  ELSD allows the detection of analytes without a chromophore.
Huber Minichiller 600HuberUsed for cooling and heating condensers at lab scale reactions (-20 °C to +40 °C). Part of our green chemistry initiative, reducing waste water (estimated to save at least 100 L per hour for each system) as coolant is recirculated
Huber CC-505HuberUsed for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C
Huber Ministat 230HuberUsed for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C
EasyMax 102Mettler ToledoEnables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction.
Radley Reactor-ReadyRadleyUniversal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project
Mya 4 Reaction StationRadleyA 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry.
EasyMax 102 (including Optimax HFCal)Mettler-ToledoEnables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction, potential risks and by-products, and is connected to a gas flow meter
ECB BoxMettler-ToledoConnects EasyMax to 3rd party sensors
Nutsche filter dryer BachillerEnables in situe drying of filtered material, reducing the handling steps in a potent environment. Agitation also allows for in-situ slurry washing of the filter cake, allowing for better reporoduction of certain manufacturing scale capabilities
TsuH.E.L groupUsed to screen different pressures and temperatures of a sample on the same platform
Filter dryerPowder SystemsIsolation of highly potent materials
Hydrogen generatorH-GenieSupply of up to 100 bar pressure of hydrogen
Isolator
CTS
Containment of highly potent materials
Agilent 1100 x 2AgilentWalk up LC-MS, coupled to ZQ Mass Spec
CatalysisGlove boxMbraun
Biotage Endeavour BiotageUsed for parallel, multi-reactor optimisation of pressurised reactions (8 x 1-4 mL tubes, up to 30 bar pressure and 200°C)
HEL Cat-96H.E.L groupUsed for high throughput catalyst screening in 96 well plates (96 x 200-1000 uL vials, up to 34 bar and 200 °C). Also available is the HEL Cat-7, used for parallel catalyst screening (7 x 3-20 mL tubes, up to 100 bar and 200 °C)
1L Buchi autoclaveBuchiAllows for pressurised reactions up to 1L at 10 bar
Miniclave Drive (300 mL)BuchiA multipurpose steel pressure reactor system  designed for use with interchangeable steel pressure vessels.
Pressflow controllerBuchi
System used to quantify the delivery of gasses
Cat 7HEL7 position reactor for manual catalyst screening
Cat 96HEL96 position reactor for manual catalyst screening
Genevac EZ-2Biopharma Groupcentrifugal solvent evaporator system
LED aquarium lamp and controllerKessilPhotoredox reactions enabled by blue light
Man on the Moonmanonthemoontech.comMonitoring hydrogen uptake in small scale hydrogenation reactions
Tumble stirrerAgitation of biotransformations
Parr hydrogenatorParr Instrument CompanyUsed for high pressure reactions, handling volumes up to 600 mL
Analytical ScienceMetrohm KF Ti-Touch and Metrohm KF TitrinoMetrohmWater determination by KF
Metrohm Coulometric KF and Thermoprep ovenMetrohmWater determination by KF (samples unamenable to direct KF titration)
Fusion S-MatrixAI method development
Powder weighing cabinet x 2SafetechSafety weighing enclosure for solids/liquids, to protect up to OEB4 (1-10ug/m3), containing 6 figure analytical balance
Agilent 1100/1200 HPLC x 4AgilentUsed for process development. 1 x equipped with quaternary pump and Variable Wavelength Detector (VWD), used for chiral analysis.
Agilent 1100/1200 HPLC-MSAgilentEquipped with ZQ mass spectrometer. Used for process development and optimisation
Agilent 1220 HPLC x 2AgilentEquipped with DAD/VWD. Used for general project support.
Agilent 1220 HPLC-CADAgilentDAD with Charged Aerosol Detector (CAD) for analysis of compounds with poor chromophores
Agilent 1260 HPLC x 3AgilentEquipped with DAD/VWD. 1 x equipped with column switcher. Used for method development and project support
Agilent 1260 HPLC x 2AgilentEquipped with DAD and Masshunter open-access interface, for general project support
Agilent 1260 HPLC-MSAgilentEquipped with 6150 mass spectrometer. Used for process development and optimisation
Agilent 1290 UPLCAgilentUsed for method development and optimisation
Agilent 1290 UPLC x 2Agilent1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission 
Agilent 1290 UPLC-MS x 2Agilent1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission. iQ mass detector allows for process optimisation
Waters ACQUITY I-Class UPLC-MSWatersEquipped with Triple Quadrupole Detector (TQD) and 4 column manager, used for rapid method screening, with open access software
Waters ACQUITY H-Class UPLC-MSWatersEquipped with QDa mass detector, 4 column switcher with open access software
Shimadzu LC20/30 HPLCShimadzuEquipped with 6 way column switcher for rapid reverse-phase chiral screening system
Thermo Vanquish Duo UPLC-CAD-MSThermoEquipped with CAD, MS and reverse gradient for ID and quantification of compounds and impurities with poor chromophores
Agilent 7890B GC-FID AgilentEquipped with dual Flame Ionisation Detector (FID) and dual injector
Agilent 6890N GC-FIDAgilentEquipped with dual Flame Ionisation Detector (FID), headspace sample injector
Agilent 8890 GC-FID-MSAgilentEquipped with a single-quadropole MS for impurity identification
Agilent 8890 FID-VUVAgilent/VUVEquipped with Flame ionisation Detector and Vacuum UV detector to allow analysis of trace levels including moisture, and solvents in a single analytical method  
Shimadzu i-series 2050 x 2ShimadzuUsed for routine sample analysis (integrated with LabSolutions DCS)
Shimadzu XS UPLCShimadzuUsed for rapid method screening and method optimisation
Shimadzu LC40 LC-MS 2020ShimadzuImpurity identification (integrated with LabSolutions DCS)
Shimadzu GC-MS 2020NXShimadzuAlso has FID detector. Impurity identification (integrated with LabSolutions DCS)
Shimadzu GC OAC6000ShimadzuGC-FID system for routine sample analysis (integrated with LabSolutions DCS)
Labsolutions ShimadzuUsed for GMP chromatography data system
LabwareLabwareUsed for GMP LIMS/ELN 
Thermal Screening UnitHELFor identifying thermal and pressure hazards in reaction mixes and raw material liquids and powders
JEOL 400MHz NMRJeolEquipped with 30 place autosampler – Used for in-house process development, confirmation of structure and assay
ICP-MSShimadzuResidual metals analysis and ICHQ3D 
Agilent 1290 UPLC-QTOFAgilentEquipped with triple quad MS/MS, high-resolution MS, ability to analyse larger molecular weight compounds such as oligonucleotides
Shimadzu Tm-UVShimadzuUV instrument with temperature modifying capability to enable analysis of oligonucleotides
Fusion S-MatrixSoftware platform which allows method development, analytical QbD and method robustness determination 
Crystallisation, Solid State and PreformulationParallel Crystalliser – Crystal 16TechnobisUsed to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL
CrystallineTechnobisCrystallisation process design up to 8 mL with overhead stirring 
FTIRShimadzuUsed to confirm the identity of a material and to differentiate between polymorphs
DSCMettler ToledoThermal and thermodynamic stability of materials with autosampler
EquaVAP EvaporatorEquaVAPUsed to evaporate solvent from vials in plates
XRPDMalvern PanalyticalIdentification of solid state forms
VacMaster Filtration UnitBiotageUsed to assess filtrations before scale-up
TGAMettler ToledoLevels of loosely bound solvent
Hot Stage MicroscopeLeicaAssessment of crystallinity, particle shape and size, and polymorph change at varying temperatures
MicroscopeZeissHigh resolution assessment of crystallinity, particle shape and size
Lab scale fluid energy millFPSUsed to control the size of seed used in crystallisation studies
Tapped bulk density Anton-PaarUsed to assess flowability of powders handled 
Malvern 3000 particle sizerMalvern PanalyticalParticle size measurements
Stability chambersCamlabInvestigational stability of drug substance and drug product
Stability ovenMemmertUsed to evaluate the stability of API over time under controlled temperature, humidity and light environments
Blaze 900 probeBlazeUsed for in-process particle characterisation by imaging and chord length distribution analysis
Radley Reactor-ReadyRadleyUniversal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project
microDISS ProfilerPionUsed to measure the dissolution profiles of API in physilogic media
DVS Intrinsic PlusSurface Measurement Systems Ltd.Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid
Mya 4 Reaction StationRadleyA 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry.