Our Equipment

Key Equipment Type Brand Comment
Process R&D – Standard 20L jacketed vessels Diehm Used to produce specimen scale-up batches up to around 1 kg
EasySampler Mettler-Toledo Automated sampling and reaction profile monitoring, including  air sensitive reactions
5L filtration equipment Used for large scale filtrations under positive or negative pressure, with heat jacket and overhead stirring
Huber Unistat 360 Huber Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C
Huber Unistat 430 Huber Used for heating and cooling reactors between 5 and 20 L from -40 °C to +250 °C
Huber Ministat 230 Huber Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C
Biotage microwave reactor Biotage Used for microwave reaction screenings, from 2.5 to 5mL, up to 20 bar and temperature range of 60 °C to 250 °C with automated sample processing
Freeze dryer SP Scientific Used to remove water from samples at sub zero temperature
Heidolph Distimatic Heidolph Automated distillation & concentration of solvents, from 500 mL to > 20 L. Fully automated system, used mostly for large-scale processes
Synthia Merck Millipore Automated retrosynthesis
Chemicalize ChemAxon pKa, logP and 1H NMR predictions
DynoChem Scale-up Systems Modelling software to enhance process understanding and develop scalable, robust unit operations quickly with reduced experimentation
Process R&D – OEB-5 EasyMax Mettler Toledo A 2-zone reaction station offering safe and precise heating, active cooling, software control and remote data-logging for 24/7 unattended chemistry.
Greenhouse evaporator Radleys Low footprint concentration of high hazard solutions within an isolator environment
VChamber MeltPrep Low footprint drying of high hazard solids within an isolator environment
Isolator CTS Handling of compounds with OEL’s less than 0.03 µg/m3.
Process R&D – OEB-4 Controlled Substances Box Used for keeping highly potent, pharmacologically active controlled substances. Keyholders strictly controlled & registered with Home Office; contents routinely audited to ensure compliance
Flash Purification System Biotage Biotage Isolera One Automated flash system
Huber Minichiller 600 Huber Used for cooling and heating condensers at lab scale reactions (-20 °C to +40 °C). Part of our green chemistry initiative, reducing waste water (estimated to save at least 100 L per hour for each system) as coolant is recirculated
Huber CC-505 Huber Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C
Huber Ministat 230 Huber Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C
Radley Reactor-Ready Radley Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project
Mya 4 Reaction Station Radley A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry.
EasyMax 102 (including Optimax HFCal) Mettler-Toledo Enables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction, potential risks and by-products, and is connected to a gas flow meter
ECB Box Mettler-Toledo Connects EasyMax to 3rd party sensors
Nutsche filter dryer Bachiller Enables in situe drying of filtered material, reducing the handling steps in a potent environment. Agitation also allows for in-situ slurry washing of the filter cake, allowing for better reporoduction of certain manufacturing scale capabilities
Tsu H.E.L group Used to screen different pressures and temperatures of a sample on the same platform
Filter dryer Powder Systems Isolation of highly potent materials
Agilent 1100 x 2 Agilent Walk up LC-MS, coupled to ZQ Mass Spec
Catalysis Glove box Mbraun 10 m3 Glovebox maintained at < 10 ppm O2, used for catalyst screening and sensitive reactions. Equipped with twin purifier system and 30 gloves
Biotage Endeavour Biotage Used for parallel, multi-reactor optimisation of pressurised reactions (8 x 1-4 mL tubes, up to 30 bar pressure and 200°C)
HEL Cat-96 H.E.L group Used for high throughput catalyst screening in 96 well plates (96 x 200-1000 uL vials, up to 34 bar and 200 °C). Also available is the HEL Cat-7, used for parallel catalyst screening (7 x 3-20 mL tubes, up to 100 bar and 200 °C)
1L Buchi autoclave Buchi Allows for pressurised reactions up to 1L at 10 bar
Parr hydrogenator Parr Instrument Company Used for high pressure reactions, handling volumes up to 600 mL
Analytical Science Metrohm KF Ti-Touch and Metrohm KF Titrino Metrohm Water determination by KF
Metrohm Coulometric KF and Thermoprep oven Metrohm Water determination by KF (difficult samples)
Percepta ACD In silico method development
Powder weighing cabinet x 2 Safetech Safety weighing enclosure for solids/liquids, to protect up to OEB4 (1-10ug/m3), containing 6 figure analytical balance
Agilent 1220 HPLC x 2 Agilent Equipped with DAD/VWD, general project support
Agilent 1220 HPLC Agilent Equipped with DAD/VWD, general project support (DAD setup with Charged Aerosol Detector (CAD) for analysis of compounds with poor chromophores)
Agilent 1100 HPLC x 2 Agilent Equipped with quaternary pump and Variable Wavelength Detector (VWD), used for chiral analysis
Agilent 1260 HPLC with column switcher Agilent Used for method development
Agilent 1100/1200  LC-MS Agilent LC-MS systems (ZQ) for Process Development and optimisation
Agilent 1100/1200 Agilent Used for process development
Agilent 1290 UPLC-UV Agilent 1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission
Agilent 1260 HPLC x 3 Agilent Equipped with DAD and Masshunter open-access interface, general project support
Waters ACQUITY I-Class UPLC Waters Equipped with Triple Quadrupole Detector (TQD) and 4 column manager, used for rapid method screening, with open access software
Waters ACQUITY H-Class UPLC Waters Equipped with QDa mass detector, 4 column switcher (can be configured to run CAD), with open access software
Shimadzu LC20/30 HPLC Shimadzu Equipped with 6 way column switcher for chiral screening system
Varian 3800 Saturn 2000 MS GC-MS Varian Equipped with ion trap
Agilent 7890B GC-FID Agilent Equipped with dual Flame Ionisation Detector (FID) and dual injector
Agilent 6890N GC-FID Agilent Equipped with dual Flame Ionisation Detector (FID), single injector with headspace sample injector
Reverse-phase Shimadzu HPLC-UV Shimadzu 6 column switcher with multiple eluent channels for automated rapid chiral method screening
Shimadzu i-series 2050 x 2 Shimadzu Used for routine sample analysis (integrated with LabSolutions DCS)
Shimadzu XS UPLC Shimadzu Used for rapid method screening and method optimisation
Shimadzu LC40 LC-MS 2020 Shimadzu Impurity identification (integrated with LabSolutions DCS)
Shimadzu GC-MS 2020NX Shimadzu Also has FID detector. Impurity identification (integrated with LabSolutions DCS)
Shimadzu GC OAC6000 Shimadzu GC-FID system for routine sample analysis (integrated with LabSolutions DCS)
Labsolutions Shimadzu Used for GMP chromatography data system
Labware Labware Used for GMP LIMS/ELN
Thermal Screening Unit HEL For identifying thermal and pressure hazards in reaction mixes and raw material liquids and powders
JEOL 400MHz NMR Jeol Equipped with 30 place autosampler – Used for in-house process development, confirmation of structure and assay
ICP-MS Shimadzu Residual metals analysis and ICHQ3D
Material Science Parallel Crystalliser – Crystal 16 Technobis Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL
Crystalline Technobis Crystallisation process design up to 8 mL with overhead stirring
FTIR Shimadzu Used to confirm the identity of a material and to differentiate between polymorphs
DSC Mettler Toledo Thermal and thermodynamic stability of materials with autosampler
EquaVAP Evaporator EquaVAP Used to evaporate solvent from vials in plates
XRPD Malvern Panalytical Identification of solid state forms
VacMaster Filtration Unit Biotage Used to assess filtrations before scale-up
TGA Mettler Toledo Levels of loosely bound solvent
Microscope Leica High resolution assessment of crystallinity, particle shape and size
Microscope Zeiss Assessment of crystallinity and particle shape, and futureproofed for hot stage work
Lab scale fluid energy mill FPS Used to control the size of seed used in crystallisation studies
Tapped bulk density Anton-Paar Used to assess flowability of powders handled
Malvern 3000 particle sizer Malvern Panalytical Particle size measurements
Stability chambers Camlab Investigational stability of drug substance and drug product
Stability oven Memmert Used to evaluate the stability of API over time under controlled temperature, humidity and light environments
Blaze 900 probe Blaze Used for in-process particle characterisation by imaging and chord length distribution analysis
Radley Reactor-Ready Radley Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project
microDISS Profiler Pion Used to measure the dissolution profiles of API in physilogic media
DVS Intrinsic Plus Surface Measurement Systems Ltd. Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid
Mya 4 Reaction Station Radley A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry