|
Key Equipment Type |
Brand |
Comment |
| Crystallisation, Solid State and Preformulation |
Parallel Crystalliser – Crystal 16 |
Technobis |
Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL |
| Crystalline |
Technobis |
Crystallisation process design up to 8 mL with overhead stirring |
| FTIR |
Shimadzu |
Used to confirm the identity of a material and to differentiate between polymorphs |
| DSC |
Mettler Toledo |
Thermal and thermodynamic stability of materials with autosampler |
| EquaVAP Evaporator |
EquaVAP |
Used to evaporate solvent from vials in plates |
| XRPD |
Malvern Panalytical |
Identification of solid state forms |
| VacMaster Filtration Unit |
Biotage |
Used to assess filtrations before scale-up |
| TGA |
Mettler Toledo |
Levels of loosely bound solvent |
| Microscope |
Leica |
High resolution assessment of crystallinity, particle shape and size |
| Microscope |
Zeiss |
Assessment of crystallinity and particle shape, and futureproofed for hot stage work |
| Lab scale fluid energy mill |
FPS |
Used to control the size of seed used in crystallisation studies |
| Tapped bulk density |
Anton-Paar |
Used to assess flowability of powders handled |
| Malvern 3000 particle sizer |
Malvern Panalytical |
Particle size measurements |
| Stability chambers |
Camlab |
Investigational stability of drug substance and drug product |
| Stability oven |
Memmert |
Used to evaluate the stability of API over time under controlled temperature, humidity and light environments |
| Blaze 900 probe |
Blaze |
Used for in-process particle characterisation by imaging and chord length distribution analysis |
| Radley Reactor-Ready |
Radley |
Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
| microDISS Profiler |
Pion |
Used to measure the dissolution profiles of API in physilogic media |
| DVS Intrinsic Plus |
Surface Measurement Systems Ltd. |
Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid |
| Mya 4 Reaction Station |
Radley |
A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry |
