|
Key Equipment Type |
Brand |
Comment |
Crystallisation, Solid State and Preformulation |
Parallel Crystalliser – Crystal 16 |
Technobis |
Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL |
Crystalline |
Technobis |
Crystallisation process design up to 8 mL with overhead stirring |
FTIR |
Shimadzu |
Used to confirm the identity of a material and to differentiate between polymorphs |
DSC |
Mettler Toledo |
Thermal and thermodynamic stability of materials with autosampler |
EquaVAP Evaporator |
EquaVAP |
Used to evaporate solvent from vials in plates |
XRPD |
Malvern Panalytical |
Identification of solid state forms |
VacMaster Filtration Unit |
Biotage |
Used to assess filtrations before scale-up |
TGA |
Mettler Toledo |
Levels of loosely bound solvent |
Microscope |
Leica |
High resolution assessment of crystallinity, particle shape and size |
Microscope |
Zeiss |
Assessment of crystallinity and particle shape, and futureproofed for hot stage work |
Lab scale fluid energy mill |
FPS |
Used to control the size of seed used in crystallisation studies |
Tapped bulk density |
Anton-Paar |
Used to assess flowability of powders handled |
Malvern 3000 particle sizer |
Malvern Panalytical |
Particle size measurements |
Stability chambers |
Camlab |
Investigational stability of drug substance and drug product |
Stability oven |
Memmert |
Used to evaluate the stability of API over time under controlled temperature, humidity and light environments |
Blaze 900 probe |
Blaze |
Used for in-process particle characterisation by imaging and chord length distribution analysis |
Radley Reactor-Ready |
Radley |
Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
microDISS Profiler |
Pion |
Used to measure the dissolution profiles of API in physilogic media |
DVS Intrinsic Plus |
Surface Measurement Systems Ltd. |
Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid |
Mya 4 Reaction Station |
Radley |
A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry |