| Key Equipment Type | Brand | Comment |
Crystallisation, Solid State and Preformulation | Parallel Crystalliser – Crystal 16 | Technobis | Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL |
Crystalline | Technobis | Crystallisation process design up to 8 mL with overhead stirring |
FTIR | Shimadzu | Used to confirm the identity of a material and to differentiate between polymorphs |
DSC | Mettler Toledo | Thermal and thermodynamic stability of materials with autosampler |
EquaVAP Evaporator | EquaVAP | Used to evaporate solvent from vials in plates |
XRPD | Malvern Panalytical | Identification of solid state forms |
VacMaster Filtration Unit | Biotage | Used to assess filtrations before scale-up |
TGA | Mettler Toledo | Levels of loosely bound solvent |
Hot Stage Microscope | Leica | Assessment of crystallinity, particle shape and size, and polymorph change at varying temperatures | |
Microscope | Zeiss | Assessment of crystallinity and particle shape, and futureproofed for hot stage work |
Lab scale fluid energy mill | FPS | Used to control the size of seed used in crystallisation studies |
Tapped bulk density | Anton-Paar | Used to assess flowability of powders handled |
Malvern 3000 particle sizer | Malvern Panalytical | Particle size measurements |
Stability chambers | Camlab | Investigational stability of drug substance and drug product |
Stability oven | Memmert | Used to evaluate the stability of API over time under controlled temperature, humidity and light environments |
Blaze 900 probe | Blaze | Used for in-process particle characterisation by imaging and chord length distribution analysis |
Radley Reactor-Ready | Radley | Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
microDISS Profiler | Pion | Used to measure the dissolution profiles of API in physilogic media |
DVS Intrinsic Plus | Surface Measurement Systems Ltd. | Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid |
Mya 4 Reaction Station | Radley | A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry |