| Key Equipment Type | Brand | Comment |
Process R&D – Standard | Amigo reactor | Amigochem | Sampling and dilution of materials taken from the Integrity 10 reactor |
Antistatic kit universal | Mettler Toledo | To assist with the weighing of static materials |
250 mL-5L jacketed vessels | Radleys | |
20L jacketed vessels | Labtex | Used to produce specimen scale-up batches up to around 1 kg |
EasySampler | Mettler-Toledo | Automated sampling and reaction profile monitoring, including air sensitive reactions. |
250mL-5L filtration equipment | | Used for large scale filtrations under positive or negative pressure, with heat jacket and overhead stirring |
Huber Unistat 360 | Huber | Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C |
Huber Unistat 430 | Huber | Used for heating and cooling reactors between 5 and 20 L from -40 °C to +250 °C |
Huber Ministat 230 | Huber | Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C |
Heidolph Distimatic | Heidolph | Automated distillation & concentration of solvents, from 500 mL to > 20 L. Fully automated system, used mostly for large-scale processes |
Chemicalize | ChemAxon | pKa, logP and 1H NMR predictions |
Mya 4 Reaction Station | Radleys | A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. |
SP-50 dosing unit | Mettler Toledo | Adding solutions to a vessel with feedback control to other peripherals |
Hot stage microscope | Zeiss | High resolution assessment of crystallinity, particle shape and size |
Integrity 10 | | Allows 10 tube-scale reactions to be performed in parallel with independent control of stirirng and heating |
JMP 12 | JMP | Statistical data analysis software |
pH meter | Hanna | |
Centrifuge | Hettich | |
Cold plate | | Maintaining a constant subambient temperature for chemistry performed in vials |
Crystal 16 | Technobis | Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL |
DSC | Mettler Toledo | Thermal and thermodynamic stability of materials with autosampler |
Distimatic | Heidolph | Automated distillation unit |
ELN | Revvity Signals | Electronic lab notebook |
EquaVAP Evaporator | EquaVAP | Used to evaporate solvent from vials in plates |
Isolera | Biotage | Automated flash system |
Karl Fischer coulometry | Metrohm | Detection of water content of samples |
Labgear | | Lab automation software |
Melting point apparatus | | Establishing the melting point of solids |
Microscope Axioscope 5 | Zeiss | High resolution assessment of crystallinity, particle shape and size |
MestreNova | Mestrelab | A suite of software to process analytical chemistry data |
Polar Bear Plus | Cambridge Reactor Design | A heating and cooling plate that stirs and heats and cools from -40 °C to 150 °C. |
RX10 units | Mettler Toledo | RX-10 chemical reactor control system that automates jacketed laboratory reactors to ensure excellent reaction control and data-rich experimentation |
Seven Excellence pH meter | Mettler Toledo | A multi-channel benchtop pH meter for precise measurements of pH, conductivity, dissolved oxygen, and ion concentration |
TGA | Mettler Toledo | Measuring levels of loosely bound solvent |
TSu | HEL | Fast screening of thermal and pressure hazards |
VacMaster filtration unit | Biotage | Assessment of the filtration performance of parallel samples. |
Zotero | Zotero | Reference management system |
Vapourtec R series | Vapourtec | Flow reactor, pump, UV-150 photoreactor and autosampler |
DynoChem | Mettler Toledo | Modelling software to enhance process understanding and develop scalable, robust unit operations quickly with reduced experimentation |
Process R&D – OEB-5 | EasyMax | Mettler Toledo | A 2-zone reaction station offering safe and precise heating, active cooling, software control and remote data-logging for 24/7 unattended chemistry. |
Greenhouse evaporator | Radleys | Low footprint concentration of high hazard solutions within an isolator environment |
VChamber | MeltPrep | Low footprint drying of high hazard solids within an isolator environment |
Isolator | CTS | Handling of compounds with OEL’s less than 0.03 µg/m3. |
Process R&D – OEB-4 | Controlled Substances Box | | Used for keeping highly potent, pharmacologically active controlled substances. Keyholders strictly controlled & registered with Home Office; contents routinely audited to ensure compliance |
Selekt and ELSD | Biotage | Automated flash system. ELSD allows the detection of analytes without a chromophore. |
Huber Minichiller 600 | Huber | Used for cooling and heating condensers at lab scale reactions (-20 °C to +40 °C). Part of our green chemistry initiative, reducing waste water (estimated to save at least 100 L per hour for each system) as coolant is recirculated |
Huber CC-505 | Huber | Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C |
Huber Ministat 230 | Huber | Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C |
EasyMax 102 | Mettler Toledo | Enables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction. |
Radley Reactor-Ready | Radley | Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
Mya 4 Reaction Station | Radley | A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. |
EasyMax 102 (including Optimax HFCal) | Mettler-Toledo | Enables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction, potential risks and by-products, and is connected to a gas flow meter |
ECB Box | Mettler-Toledo | Connects EasyMax to 3rd party sensors |
Nutsche filter dryer | Bachiller | Enables in situe drying of filtered material, reducing the handling steps in a potent environment. Agitation also allows for in-situ slurry washing of the filter cake, allowing for better reporoduction of certain manufacturing scale capabilities |
Tsu | H.E.L group | Used to screen different pressures and temperatures of a sample on the same platform |
Filter dryer | Powder Systems | Isolation of highly potent materials |
Hydrogen generator | H-Genie | Supply of up to 100 bar pressure of hydrogen |
Isolator | CTS | Containment of highly potent materials |
Agilent 1100 x 2 | Agilent | Walk up LC-MS, coupled to ZQ Mass Spec |
Catalysis | Glove box | Mbraun | 10 m3 Glovebox maintained at < 10 ppm O2, used for catalyst screening and sensitive reactions. Equipped with twin purifier system and 30 gloves. |
Biotage Endeavour | Biotage | Used for parallel, multi-reactor optimisation of pressurised reactions (8 x 1-4 mL tubes, up to 30 bar pressure and 200°C) |
HEL Cat-96 | H.E.L group | Used for high throughput catalyst screening in 96 well plates (96 x 200-1000 uL vials, up to 34 bar and 200 °C). Also available is the HEL Cat-7, used for parallel catalyst screening (7 x 3-20 mL tubes, up to 100 bar and 200 °C) |
1L Buchi autoclave | Buchi | Allows for pressurised reactions up to 1L at 10 bar |
Miniclave Drive (300 mL) | Buchi | A multipurpose steel pressure reactor system designed for use with interchangeable steel pressure vessels. |
Pressflow controller | Buchi | System used to quantify the delivery of gasses |
Cat 7 | HEL | 7 position reactor for manual catalyst screening |
Cat 96 | HEL | 96 position reactor for manual catalyst screening |
Genevac EZ-2 | Biopharma Group | centrifugal solvent evaporator system |
LED aquarium lamp and controller | Kessil | Photoredox reactions enabled by blue light |
Man on the Moon | manonthemoontech.com | Monitoring hydrogen uptake in small scale hydrogenation reactions |
Tumble stirrer | | Agitation of biotransformations |
Parr hydrogenator | Parr Instrument Company | Used for high pressure reactions, handling volumes up to 600 mL |
Analytical Science | Metrohm KF Ti-Touch and Metrohm KF Titrino | Metrohm | Water determination by KF |
Metrohm Coulometric KF and Thermoprep oven | Metrohm | Water determination by KF (samples unamenable to direct KF titration) |
Fusion | S-Matrix | AI method development |
Powder weighing cabinet x 2 | Safetech | Safety weighing enclosure for solids/liquids, to protect up to OEB4 (1-10ug/m3), containing 6 figure analytical balance |
Agilent 1100/1200 HPLC x 4 | Agilent | Used for process development. 1 x equipped with quaternary pump and Variable Wavelength Detector (VWD), used for chiral analysis. |
Agilent 1100/1200 HPLC-MS | Agilent | Equipped with ZQ mass spectrometer. Used for process development and optimisation |
Agilent 1220 HPLC x 2 | Agilent | Equipped with DAD/VWD. Used for general project support. |
Agilent 1220 HPLC-CAD | Agilent | DAD with Charged Aerosol Detector (CAD) for analysis of compounds with poor chromophores |
Agilent 1260 HPLC x 3 | Agilent | Equipped with DAD/VWD. 1 x equipped with column switcher. Used for method development and project support |
Agilent 1260 HPLC x 2 | Agilent | Equipped with DAD and Masshunter open-access interface, for general project support |
Agilent 1260 HPLC-MS | Agilent | Equipped with 6150 mass spectrometer. Used for process development and optimisation |
Agilent 1290 UPLC | Agilent | Used for method development and optimisation |
Agilent 1290 UPLC x 2 | Agilent | 1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission |
Agilent 1290 UPLC-MS x 2 | Agilent | 1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission. iQ mass detector allows for process optimisation |
Agilent 6550LC/Q-TQF MS | Agilent | High Resolution Accurate Mass MS/MS instrument for Compound ID, analysis of large molecules (Oligos, Peptides, etc), trace analysis (GI’s and Nitrosamines) and complex mixture analysis |
Agilent 6550 iFunnel Q-Tof LC/MS | Agilent | High Resolution Accurate Mass MS/MS instrument for Compound ID, analysis of large molecules (Oligos, Peptides, etc), trace analysis (GI’s and Nitrosamines) and complex mixture analysis |
Waters ACQUITY I-Class UPLC-MS | Waters | Equipped with Triple Quadrupole Detector (TQD) and 4 column manager, used for rapid method screening, with open access software |
Waters ACQUITY H-Class UPLC-MS | Waters | Equipped with QDa mass detector, 4 column switcher with open access software |
Shimadzu LC20/30 HPLC | Shimadzu | Equipped with 6 way column switcher for rapid reverse-phase chiral screening system |
Thermo Vanquish Duo UPLC-CAD-MS x 2 | Thermo | Equipped with CAD and DAD and dual pumps for reverse gradient. Applied to the quantification of compounds and impurities with poor chromophores |
Agilent 7890B GC-FID | Agilent | Equipped with dual Flame Ionisation Detector (FID) and dual injector |
Agilent 6890N GC-FID | Agilent | Equipped with dual Flame Ionisation Detector (FID), headspace sample injector |
Agilent 8890 GC-FID-MS | Agilent | Equipped with a single-quadropole MS for impurity identification |
Agilent 8890 FID-VUV | Agilent/VUV | Equipped with Flame ionisation Detector and Vacuum UV detector to allow analysis of trace levels including moisture, and solvents in a single analytical method |
Shimadzu i-series 2050 x 2 | Shimadzu | Used for routine sample analysis (integrated with LabSolutions DCS) |
Shimadzu XS UPLC | Shimadzu | Used for rapid method screening and method optimisation |
Shimadzu LC40 LC-MS 2020 | Shimadzu | Impurity identification (integrated with LabSolutions DCS) |
Shimadzu GC-MS 2020NX | Shimadzu | Also has FID detector. Impurity identification (integrated with LabSolutions DCS) |
Shimadzu GC OAC6000 | Shimadzu | GC-FID system for routine sample analysis (integrated with LabSolutions DCS) |
Labsolutions | Shimadzu | Used for GMP chromatography data system |
Labware | Labware | Used for GMP LIMS/ELN |
Thermal Screening Unit | HEL | For identifying thermal and pressure hazards in reaction mixes and raw material liquids and powders |
JEOL 400MHz NMR | Jeol | Equipped with 30 place autosampler – Used for in-house process development, confirmation of structure and assay |
ICP-MS | Shimadzu | Residual metals analysis and ICHQ3D |
Agilent 1290 UPLC-QTOF | Agilent | Equipped with MS/MS capability, with a high-resolution TOF stage with, ability to analyse larger molecular weight compounds such as oligonucleotides |
Shimadzu Tm-UV | Shimadzu | UV instrument with temperature modifying capability to enable analysis of oligonucleotides |
Crystallisation, Solid State and Preformulation | Parallel Crystalliser – Crystal 16 | Technobis | Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL |
Crystalline | Technobis | Crystallisation process design up to 8 mL with overhead stirring |
FTIR | Shimadzu | Used to confirm the identity of a material and to differentiate between polymorphs |
DSC | Mettler Toledo | Thermal and thermodynamic stability of materials with autosampler |
EquaVAP Evaporator | EquaVAP | Used to evaporate solvent from vials in plates |
XRPD | Malvern Panalytical | Identification of solid state forms |
VacMaster Filtration Unit | Biotage | Used to assess filtrations before scale-up |
TGA | Mettler Toledo | Levels of loosely bound solvent |
Hot Stage Microscope | Leica | Assessment of crystallinity, particle shape and size, and polymorph change at varying temperatures |
Microscope | Zeiss | High resolution assessment of crystallinity, particle shape and size |
Lab scale fluid energy mill | FPS | Used to control the size of seed used in crystallisation studies |
Tapped bulk density | Anton-Paar | Used to assess flowability of powders handled |
Malvern 3000 particle sizer | Malvern Panalytical | Particle size measurements |
Stability chambers | Camlab | Investigational stability of drug substance and drug product |
Stability oven | Memmert | Used to evaluate the stability of API over time under controlled temperature, humidity and light environments |
Blaze 900 probe | Blaze | Used for in-process particle characterisation by imaging and chord length distribution analysis |
Radley Reactor-Ready | Radley | Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project |
microDISS Profiler | Pion | Used to measure the dissolution profiles of API in physilogic media |
DVS Intrinsic Plus | Surface Measurement Systems Ltd. | Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid |
Mya 4 Reaction Station | Radley | A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry. |
Oligonucleotides PR&D | MerMade 12 Oligonucleotide Synthesiser | LGC | 50 nmol to 200 µmol synthesis scale. Medium throughput synthesier with a 12 column configuration and 20 amidite positions. |
ÄKTA OligoSynt™ | Cytiva | 10 µmol to 12 mmol synthesis scale. Compact, fully automated oligonucleotide synthesizer with broad scale for robust and scalable process development and transfer to manufacturing |
Oligonucleotides Analytical | Agilent 1290 Infinity II UPLC | Agilent | |
Agilent 1290 Infinity II Prep-LC | Agilent | |
Agilent AdvanceBio 6545XT QToF w/ BioConfirm | Agilent | |
ThermoFisher NanoDrop One-C | ThermoFisher | |