• 6 Oct 2022
  • Antonio M. Ruda, Siân M. Forsyth

Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of Solid Tumors: Lessons in Ortho-Bromination, Selective Solubility, Pd Deactivation, and Form Control

  • Catalysis
  • CatSci Paper
  • Green Chemistry
  • Process R&D
  • Scale-up
  • Papers

Resources & Insights

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Designing Therapeutic Oligonucleotides – A Practical Framework from Biology to Sequence Selection
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Peptide Design in Contemporary DMTA Cycles: How DMTA Drives Translational Refinement
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  • DMTA
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  • Loïc Roux
Is Fragmented Discovery the Silent Saboteur of Complex Medicines?
  • Design-Make-Test
  • DMTA
  • Drug Discovery
  • Thought Leaders
  • 8 Dec 2025
  • Alison Gordon, Kathy Dodgson, Ryan Mordue, Tom Miller, Vesna Vetma O'Leary
PROductive TACtics Streamlined, multifaceted approaches to unlocking PROTAC® screening insights
  • Bioscience
  • Case Studies
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