TACs and Glues
Your Partner in Advanced Targeted Protein Degrader Development
We combine chemistry, deep analytical insight, and translational bioscience to accelerate the design, synthesis, and development of degraders and molecular glues.
From route scouting to proof-of-concept and scale-up, we turn complexity into robust process understanding.
- Overview
- Capabilities across the degrader lifecycle
- Dedicated infrastructure for protein degraders
- Direct-to-Biology for degraders & glues
- Why choose us
- In our own words
- FAQs
Targeted Protein Degraders (TPDs) hold huge therapeutic promise, but also present unique challenges. TACs are complex bifunctional molecules with poor solubility, scalability risks, analytical blind spots, and proof-of-concept delays, whilst molecular glues have a complex biology that often requires a bespoke solution.
At CatSci, we enable you to overcome these hurdles with end-to-end workflows and phase-appropriate strategies tailored to your needs. We ensure your degrader programme moves forward faster and with fewer risks.
Dedicated Infrastructure for Protein Degraders
Direct-to-Biology for Degraders & Glues
Traditional degrader development often stalls because purification steps slow down iteration. With our Direct-to-Biology (D2B) approach, we bypass these bottlenecks by screening crude reaction mixtures directly in biological assays.
- One-step chemistries (amine coupling, photoreactions, click) executed in assay-ready plates
- Rapid testing in cell-based assays (NanoBRET, HIBiT degradation, proliferation) and biochemical assays (FP, TR-FRET)
- Accelerates hit-to-lead by cutting time and material costs
- Particularly powerful in the targeted protein degradation space, where rapid iteration is critical
The result is faster candidate identification, streamlined optimisation, and earlier biological validation.
Why Choose Us
- Trusted partner to 100+ pharma and biotech companies, including projects with over half of the global Top 10
- Cross functional degrader expertise spanning chemistry, bioscience, analytics, and purification
- Proven track record of solving complex degrader challenges with scalable, manufacturable solutions
- Safebridge-audited containment suites and robust data protection
- Transparent communication, scientist-to-scientist updates, and tailored solutions
Frequently Asked Questions
CatSci delivers end-to-end targeted protein degrader development services, covering PROTACs® and other TACs, and molecular glues. We integrate chemistry, analytical science, and bioscience to design, synthesise, purify, and validate bifunctional degraders. Our expertise spans linker design, route optimisation, stability profiling, and translational proof-of-concept to accelerate progress from discovery to IND readiness.
CatSci supports PROTAC® and molecular glue discovery through an integrated chemistry–biology framework. We design and assemble degraders using robust synthetic routes and then validate biological performance through cell-based and biochemical assays. By combining analytical precision with translational bioscience, we generate clear, decision-ready data that de-risks development and strengthens candidate selection.
CatSci’s Direct-to-Biology platform enables crude reaction mixtures to be screened directly in biological assays, removing purification bottlenecks and saving time. In targeted protein degrader development, D2B allows earlier insight into degradation efficiency, potency, and toxicity, accelerating hit-to-lead optimisation. This approach reduces cycle times, conserves materials, and speeds up proof-of-concept validation.
CatSci is a trusted partner for targeted protein degrader development because we bring together deep expertise across chemistry, analytics, and bioscience. With a proven track record in complex degrader pipelines, advanced analytical methods, and D2B integration, we provide scalable, regulatory-aligned workflows. Our transparent, scientist-to-scientist collaboration ensures every degrader programme moves forward with confidence and clarity.