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Papers

Read the team’s scientific Papers.

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Analytical Chemistry Analytical Science Artificial Intelligence (AI) Biocatalysis Catalysis CatSci Paper CatSci Patent Chemical Development Design of Experiments Digital Drug Development Experimental Design Green Chemistry Industry insights Innovation Machine Learning (ML) Material Science Medium Throughput Experimentation Oligonucleotides Principal Component Analysis Process R&D PROTACs QbD Route Scouting and Selection Scale-up Scavenging Solvents Sustainability Technology transfer Work-up
Synthesis and Development of a Nonaflate Ester in the Large-Scale Preparation of 3-Deoxymorp...

Letters in Organic Chemistry, 2024

2024 By Antonio M. RudaJonathan D. Moseley, et al.
Early Process Development and Scale-Up of Orally Active Apomorphine Drug Candidates

Org. Process Res. Dev. 2022

2022 By Antonio M. RudaEkaterina Y. MelikhovaJonathan D. MoseleyNadia Fleary-RobertsSiân M. ForsythSimon N. G. TylerSofia PapadouliVargini Thangavadivale, et al.
Application of the Polonovski Reaction: Scale-up of an Efficient and Environmentally Benign ...

Org. Process Res. Dev. 2022, 26, 5, 1398–1404

2022 By Antonio M. RudaSiân M. ForsythSofia PapadouliVargini Thangavadivale, et al.
Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of ...

Org. Process Res. Dev. 2022, 26, 5, 1458–1469

2022 By Antonio M. RudaSiân M. Forsyth, et al.
Selective Catalytic Synthesis of 1,2- and 8,9-Cyclic Limonene Carbonates as Versatile Buildi...

Chem. Eur. J., 2020, 26, 1–12

2020 By Marc Hutchby, et al.
Green Chemistry Articles of Interest to the Pharmaceutical Industry

Org. Process Res. Dev. 2020, 24, 6, 897–908

2020 By Alan Steven, et al.
Mapping the properties of bidentate ligands with calculated descriptors (LKB-bid)

Dalton Trans., 2020, 49, 8169-8178

2020 By Simon N. G. Tyler, et al.
Ketone Reductase Biocatalysis in the Synthesis of Chiral Intermediates Toward Generic Active...

Org. Process Res. Dev. 2020, 24, 6, 1131–1140

2020 By Dan A. SmithJoanne B. SampsonSiân M. Forsyth, et al.
Chemical Consequences of the Mechanical Bond: A Tandem Active Template-Rearrangement Reaction

Angew. Chem. Int. Ed., 2019, 58

2019 By Elise Rochette, et al.
Controlled Construction of Cyclic d / l Peptide Nanorods

Angew. Chem. Int. Ed., 2019, 58, 596-601

2019 By Joanne B. Sampson, et al.
Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ...

ACS Med. Chem. Lett. 2019, 10, 8, 1134–1139

2019 By Guy Brenchley, et al.
Sustainable catalytic protocols for the solvent free epoxidation and anti-dihydroxylation of...

Green Chem., 2020, 22, 513-524

2019 By Marc Hutchby, et al.
Self-complementary nickel halides enable multifaceted comparisons of intermolecular halogen ...

Chem. Sci., 2018, 9, 3767-3781

2018 By Vargini Thangavadivale, et al.
Continuous-flow liquid-phase dehydrogenation of 1,4-cyclohexanedione in a structured multich...

React. Chem. Eng., 2019, 4, 27-40

2018 By Marc Hutchby, et al.
Iron catalysis for the synthesis of ligands: Exploring the products of hydrophosphination as...

Tetrahedron 2017, 73, 64-69

2017 By Simon N. G. Tyler, et al.
An efficient and scalable process to produce morpholine-d₈

Synth. Commun. 2017, 47, 481

2017 By Dan A. Smith, et al.
An Asymmetric Pathway to Dendrobine by a Transition-Metal-Catalyzed Cascade Process

Angew. Chem. Int. Ed., 2017, 40, 12250-12254

2017 By Elise Rochette, et al.
Automation of route identification and optimisation based on data-mining and chemical intuition

Faraday Discuss., 2017,202, 483-496

2017 By Marc Hutchby, et al.
Characterization of the first naturally thermostable terpene synthases and development of st...

The FEBS Journal 284 (2017) 1700–1711

2017 By Marc Hutchby, et al.
Process for the preparation of a stereospecific form of flurbiprofen, or a pharmaceutically ...

WO2016110708

2016 By CatSci team, et al.
Dehydromicrosclerodermin B and Microsclerodermin J: Total Synthesis and Structural Revision

Angew.Chem. Int.Ed. 2016, 55, 9753

2016 By Ekaterina Y. Melikhova, et al.
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What we do

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Who we are

CatSci Ltd are an award-winning innovation partner for medicines development who are committed to creating tailored solutions from candidate selection through product launch and beyond. We break down the silos in small molecules, TACS, glues and oligonucleotides CMC development to accelerate the delivery of life-changing medicines to patients in need. 

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