Design, Make, Test, Select

Connecting Discovery and Development

Our Design–Make–Test–Select (DMTS) model is a connected workflow that bridges discovery and development to help you reduce cycle times, de-risk candidate selection, and move you quickly toward IND readiness.

Design-Make-Test-Select
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High attrition, fragmented workflows, and disconnected data remain major barriers in early drug discovery. Many promising candidates fail because traditional outsourcing models lack integration between chemistry, biology, and CMC development.

Our integrated discovery model unites these disciplines under one framework that we call: Design-Make-Test-Select (DMTS).

Our DMTS workflows use real-time collaboration and continuous feedback to reduce design-make-test-analyse cycle times by up to 40% while delivering stronger, more developable drug candidates.

Our Design-Make-Test-Select Workflow
Design: Chemistry & Consultation
Sequence and structure optimisation guided by SAR insight and developability assessments. Our scientists collaborate with your team to translate early hypotheses into scalable, testable chemistry.
Make: Synthesis & Purification
Our expert chemists use automation to deliver rapid parallel synthesis of peptides, oligonucleotides, and bRo5 molecules. Integrated purification and analytical control ensure consistency and readiness for biological evaluation.
Test: Bioscience Expertise
Tailored biochemical and cell-based assays evaluate efficacy, uptake, stability, and toxicity. Our co-located bioscience team generates in vitro data that’s biologically relevant and decision-ready.
Analyse: Data Insight & Decision Support
Cross-functional analysis brings it together in decision-focused data packages, ranking candidates and anticipating regulatory needs.
Select: Selecting the Best Candidate(s)
Our experts collate the data and insight gained from our iterative approach to move with velocity into in vivo and preformulation studies.

What You Achieve with DMTS

Smarter Triage
Identify weak candidates early through integrated developability profiling and parallel data generation.
Faster Progression
Enhanced collaboration and compressed timelines with connected chemistry–biology workflows that deliver data at speed.
Stronger Investor Confidence
Provide decision-ready, IND-aligned data packages that demonstrate quality, value, and readiness.
Regulatory Foresight
Generate traceable, CMC-aligned data from the start to de-risk preclinical and IND submissions.
What This Stage Enables for Your Programme
Reduced attrition
Early developability insight ensures viable candidates move forward
Accelerated IND readiness
Shorter iteration cycles and connected data sets speed up progression
Informed selection
Biological relevance meets chemical precision to strengthen decision-making
De-risked submissions
Early CMC alignment prevents last-minute surprises
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image of multi-pipette in a lab for integrated drug discovery
Design–Make–Test–Select isn’t just a workflow. It's a testament to CatSci's integration. By connecting chemistry, biology, and data from the very start, we help our partners nominate stronger, more developable candidates, faster.
Loic Roux
Technical Director, New Modalities - Drug Discovery

Frequently Asked Questions

What are integrated drug discovery services?

Integrated drug discovery services combine chemistry, bioscience, and data analytics within a single connected workflow. At CatSci, our Design–Make–Test–Select (DMTS) platform unites design, synthesis, testing, and selection to generate decision-ready data faster. This integrated approach reduces attrition, accelerates discovery timelines, and ensures every candidate is developed with CMC and regulatory foresight.

How does CatSci’s DMTS platform accelerate development?

Our DMTS platform connects design, make, test, and select stages under one collaborative framework. By aligning chemistry, analytical science, and bioscience in real time, we eliminate data silos and shorten iteration cycles by up to 40% through efficient collaboration, which enables smarter candidate prioritisation. The result is faster progression from concept to IND-ready candidates.

Which therapeutic modalities does CatSci’s DMTS model support?

Our integrated drug discovery services support multiple therapeutic modalities, including peptides, oligonucleotides, PROTACs, molecular glues, and hybrid bRo5 constructs. The DMTS model adapts to each modality’s complexity, providing connected design, synthesis, purification, and biological testing workflows that accelerate translation and de-risk development across these diverse drug types.

Book a Consultation

Speak directly with our scientists about your development challenges and explore how we can support your programme.