Peptides

Your Trusted Partner for Complex, High-Quality Peptide R&D

We combine synthetic expertise, design insight, and advanced analytical support to deliver high-quality peptide and conjugate development.

From linear and cyclic peptides to knots, macro- and multicycles, stapled frameworks, and complex conjugates, we enable biotech and pharma partners to advance their programmes with speed, confidence, and control.

High-Quality Peptide Synthesis 
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Peptides are one of the fastest-growing and exciting therapeutic areas, but they are steeped in complexity. Solubility, aggregation, and stability challenges demand deep chemical understanding and analytical precision. 

At CatSci, we bring decades of peptide expertise to every project. From hit finding through lead optimisation and early sequence design, to the scale-up of complex constrained peptides and synthesis of peptide–oligonucleotide conjugates, our scientists deliver tailored solutions. Our workflows also include custom N- and C-terminal modifications and C-terminal amide conjugates.

And if your project involves non-natural amino acids, unusual modifications – from sugars to cryptophanes – or difficult sequences, we’ll design a bespoke approach.

Integrated Capability Throughout the Peptide Development Lifecycle
Design & Synthesis
Tailored strategies for hit-finding, hit-to-lead, lead optimisation, and the creation of constrained, multi- and macrocyclic, bicyclic, and knotted peptides using parallel, automated, and manual SPPS platforms. Our workflows also include custom N- and C-terminal modifications and C-terminal amide conjugates.
Conjugates & Add-Ons
Specialised expertise in lipidation, PEGylation, fluorescent labelling, peptide–oligo conjugates, and metal chelators such as DOTA, as well as C-terminal amides for use in NCL conjugation to proteins.
In-house Purification
Expert purification is built into every project. With our co-located chromatography specialists, we ensure fast, high-resolution purification and impurity isolation for peptides at any scale.
Analytical Characterisation
Embedded analytical support ensures every peptide is fully understood. LC-MS (chiral & achiral), HRMS, NMR, and orthogonal chromatography deliver identity, purity, stability, and impurity data for total confidence.
Design-Make-Test-Select
Our integrated DMTS workflow connects design, synthesis, testing, and analysis to accelerate peptide optimisation. We unite chemistry, bioscience, and analytics to generate rapid insight that guides smarter decisions and drives faster, more confident progress.

Dedicated Infrastructure for Peptide Development

CEM Liberty PRIME™ 2.0 + HT24.0 System
Automated microwave-assisted peptide synthesis platforms enabling precise, rapid library generation and optimisation.
PurePep® Chorus 6 System
Library generation and optimisation, facilitating discovery and enabling development.
CEM Razor Platform
Delivers fast, efficient cleavage of resin-bound peptides in parallel, reducing synthesis time while maintaining product integrity and purity.
Manual SPPS Suites
Dedicated facilities for bespoke synthesis, ideal for complex or challenging sequences that demand expert control and flexibility.
Agilent 6550 iFunnel Q-TOF LC/MS System
High-resolution mass spec analytical capability for accurate mass confirmation, identity verification, and detailed impurity profiling.
Integrated Analytical and Purification Workflows
Seamless connection between synthesis, purification, and analysis ensures rapid turnaround, superior reproducibility, and exceptional peptide quality at every scale.
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Integrated Workflow

Connected Workflows for Peptide Development

Every peptide programme benefits from CatSci’s fully integrated scientific platform. From analytical characterisation and purification to hybrid conjugation and complex synthesis, our cross-functional teams work seamlessly to accelerate your molecule’s journey from design to delivery.

Why Choose Us

  • Led by experts with decades of experience with the most complex scaffolds 

  • Specialist experience in constrained, stapled, and complex peptide synthesis

  • Seamless workflow between chemistry, purification, and bioscience

  • UK-based, transparent, and collaborative partnership model

  • Proven track record delivering purity, precision, and performance

  • Supporting biotechs, start-ups, large pharma and academics worldwide with bespoke peptides  
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We don’t just make peptides — we solve problems to help you get further, faster. From simple sequences to the most challenging scaffolds, we approach every peptide with tailored solutions. Our goal is to bring purpose-built chemistry to every project, no matter how complex, to enable your success.
Jordan Fletcher
Scientific Fellow, Peptides

Frequently Asked Questions

What peptide development services does CatSci offer?

CatSci provides end-to-end peptide development services covering design, synthesis, purification, and analytical validation. Our expertise spans complex and constrained peptides, conjugates, and modified scaffolds. Using manual and automated SPPS platforms and advanced analytical tools, we deliver high-quality, scalable peptides ready for preclinical and clinical development.

Can CatSci support complex or modified peptide synthesis?

Yes. CatSci specialises in complex peptide synthesis, including cyclic, stapled, and conjugated peptides. Our scientists use advanced SPPS and purification workflows to address solubility, aggregation, and yield challenges. We tailor chemistry, analytics, and purification strategies to each sequence to ensure purity, performance, and scalability.

How does CatSci ensure peptide purity and regulatory compliance?

CatSci ensures peptide purity through integrated analytical and purification expertise, including LC-MS, Q-TOF, and preparative chromatography. All methods are developed in alignment with regulatory guidelines, ensuring data integrity and regulatory compliance. Our embedded purification capabilities deliver industry-leading quality and reproducibility for every batch.

I don’t see my peptide challenge listed, can you still help?

Absolutely. Whether it’s a difficult sequence, a custom modification, or an unusual scaffold, our team has the expertise and infrastructure to find a way forward.

From linear to stapled, cyclic, knotted, multi-and macrocyclic peptides, we thrive on complexity. If your project involves solubility issues, aggregation, or challenging synthesis routes, reach out to our experts — we’ll design a bespoke chemistry, purification, and analytical strategy to meet your goals.

Book a Consultation

Speak directly with our scientists about your development challenges and explore how we can support your programme.