Table TEMP

	Key Equipment Type	Brand	Comment
Process R&D – Standard	Amigo reactor	Amigochem	Sampling and dilution of materials taken from the Integrity 10 reactor
	Antistatic kit universal	Mettler Toledo	To assist with the weighing of static materials
	250 mL-5L jacketed vessels	Radleys
	20L jacketed vessels	Labtex	Used to produce specimen scale-up batches up to around 1 kg
	EasySampler	Mettler-Toledo	Automated sampling and reaction profile monitoring, including air sensitive reactions.
	250mL-5L filtration equipment		Used for large scale filtrations under positive or negative pressure, with heat jacket and overhead stirring
	Huber Unistat 360	Huber	Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C
	Huber Unistat 430	Huber	Used for heating and cooling reactors between 5 and 20 L from -40 °C to +250 °C
	Huber Ministat 230	Huber	Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C
	Heidolph Distimatic	Heidolph	Automated distillation & concentration of solvents, from 500 mL to > 20 L. Fully automated system, used mostly for large-scale processes
	Chemicalize	ChemAxon	pKa, logP and 1H NMR predictions
	Mya 4 Reaction Station	Radleys	A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry.
	SP-50 dosing unit	Mettler Toledo	Adding solutions to a vessel with feedback control to other peripherals
	Hot stage microscope	Zeiss	High resolution assessment of crystallinity, particle shape and size
	Integrity 10		Allows 10 tube-scale reactions to be performed in parallel with independent control of stirirng and heating
	JMP 12	JMP	Statistical data analysis software
	pH meter	Hanna
	Centrifuge	Hettich
	Cold plate		Maintaining a constant subambient temperature for chemistry performed in vials
	Crystal 16	Technobis	Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL
	DSC	Mettler Toledo	Thermal and thermodynamic stability of materials with autosampler
	Distimatic	Heidolph	Automated distillation unit
	ELN	Revvity Signals	Electronic lab notebook
	EquaVAP Evaporator	EquaVAP	Used to evaporate solvent from vials in plates
	Isolera	Biotage	Automated flash system
	Karl Fischer coulometry	Metrohm	Detection of water content of samples
	Labgear		Lab automation software
	Melting point apparatus		Establishing the melting point of solids
	Microscope Axioscope 5	Zeiss	High resolution assessment of crystallinity, particle shape and size
	MestreNova	Mestrelab	A suite of software to process analytical chemistry data
	Polar Bear Plus	Cambridge Reactor Design	A heating and cooling plate that stirs and heats and cools from -40 °C to 150 °C.
	RX10 units	Mettler Toledo	RX-10 chemical reactor control system that automates jacketed laboratory reactors to ensure excellent reaction control and data-rich experimentation
	Seven Excellence pH meter	Mettler Toledo	A multi-channel benchtop pH meter for precise measurements of pH, conductivity, dissolved oxygen, and ion concentration
	TGA	Mettler Toledo	Measuring levels of loosely bound solvent
	TSu	HEL	Fast screening of thermal and pressure hazards
	VacMaster filtration unit	Biotage	Assessment of the filtration performance of parallel samples.
	Zotero	Zotero	Reference management system
	Vapourtec R series	Vapourtec	Flow reactor, pump, UV-150 photoreactor and autosampler
	DynoChem	Mettler Toledo	Modelling software to enhance process understanding and develop scalable, robust unit operations quickly with reduced experimentation
Process R&D – OEB-5	EasyMax	Mettler Toledo	A 2-zone reaction station offering safe and precise heating, active cooling, software control and remote data-logging for 24/7 unattended chemistry.
	Greenhouse evaporator	Radleys	Low footprint concentration of high hazard solutions within an isolator environment
	VChamber	MeltPrep	Low footprint drying of high hazard solids within an isolator environment
	Isolator	CTS	Handling of compounds with OEL’s less than 0.03 µg/m3.
Process R&D – OEB-4	Controlled Substances Box		Used for keeping highly potent, pharmacologically active controlled substances. Keyholders strictly controlled & registered with Home Office; contents routinely audited to ensure compliance
	Selekt and ELSD	Biotage	Automated flash system. ELSD allows the detection of analytes without a chromophore.
	Huber Minichiller 600	Huber	Used for cooling and heating condensers at lab scale reactions (-20 °C to +40 °C). Part of our green chemistry initiative, reducing waste water (estimated to save at least 100 L per hour for each system) as coolant is recirculated
	Huber CC-505	Huber	Used for heating and cooling reactors between 2 and 20 L from -75 °C to +200 °C
	Huber Ministat 230	Huber	Used for heating and cooling reactors between 250 mL and 2 L from -40 °C to +200 °C
	EasyMax 102	Mettler Toledo	Enables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction.
	Radley Reactor-Ready	Radley	Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project
	Mya 4 Reaction Station	Radley	A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry.
	EasyMax 102 (including Optimax HFCal)	Mettler-Toledo	Enables the development of small scale reactions up to 100mL and with heating and cooling between -40 °C and +180 °C. Allows for integration of process analytical technology (PAT) or calorimetric information which enhances understanding of the progress of the reaction, potential risks and by-products, and is connected to a gas flow meter
	ECB Box	Mettler-Toledo	Connects EasyMax to 3rd party sensors
	Nutsche filter dryer	Bachiller	Enables in situe drying of filtered material, reducing the handling steps in a potent environment. Agitation also allows for in-situ slurry washing of the filter cake, allowing for better reporoduction of certain manufacturing scale capabilities
	Tsu	H.E.L group	Used to screen different pressures and temperatures of a sample on the same platform
	Filter dryer	Powder Systems	Isolation of highly potent materials
	Hydrogen generator	H-Genie	Supply of up to 100 bar pressure of hydrogen
	Isolator	CTS	Containment of highly potent materials
	Agilent 1100 x 2	Agilent	Walk up LC-MS, coupled to ZQ Mass Spec
Catalysis	Glove box	Mbraun	10 m3 Glovebox maintained at < 10 ppm O2, used for catalyst screening and sensitive reactions. Equipped with twin purifier system and 30 gloves.
	Biotage Endeavour	Biotage	Used for parallel, multi-reactor optimisation of pressurised reactions (8 x 1-4 mL tubes, up to 30 bar pressure and 200°C)
	HEL Cat-96	H.E.L group	Used for high throughput catalyst screening in 96 well plates (96 x 200-1000 uL vials, up to 34 bar and 200 °C). Also available is the HEL Cat-7, used for parallel catalyst screening (7 x 3-20 mL tubes, up to 100 bar and 200 °C)
	1L Buchi autoclave	Buchi	Allows for pressurised reactions up to 1L at 10 bar
	Miniclave Drive (300 mL)	Buchi	A multipurpose steel pressure reactor system designed for use with interchangeable steel pressure vessels.
	Pressflow controller	Buchi	System used to quantify the delivery of gasses
	Cat 7	HEL	7 position reactor for manual catalyst screening
	Cat 96	HEL	96 position reactor for manual catalyst screening
	Genevac EZ-2	Biopharma Group	centrifugal solvent evaporator system
	LED aquarium lamp and controller	Kessil	Photoredox reactions enabled by blue light
	Man on the Moon	manonthemoontech.com	Monitoring hydrogen uptake in small scale hydrogenation reactions
	Tumble stirrer		Agitation of biotransformations
	Parr hydrogenator	Parr Instrument Company	Used for high pressure reactions, handling volumes up to 600 mL
Analytical Science	Metrohm KF Ti-Touch and Metrohm KF Titrino	Metrohm	Water determination by KF
	Metrohm Coulometric KF and Thermoprep oven	Metrohm	Water determination by KF (samples unamenable to direct KF titration)
	Fusion	S-Matrix	AI method development
	Powder weighing cabinet x 2	Safetech	Safety weighing enclosure for solids/liquids, to protect up to OEB4 (1-10ug/m3), containing 6 figure analytical balance
	Agilent 1100/1200 HPLC x 4	Agilent	Used for process development. 1 x equipped with quaternary pump and Variable Wavelength Detector (VWD), used for chiral analysis.
	Agilent 1100/1200 HPLC-MS	Agilent	Equipped with ZQ mass spectrometer. Used for process development and optimisation
	Agilent 1220 HPLC x 2	Agilent	Equipped with DAD/VWD. Used for general project support.
	Agilent 1220 HPLC-CAD	Agilent	DAD with Charged Aerosol Detector (CAD) for analysis of compounds with poor chromophores
	Agilent 1260 HPLC x 3	Agilent	Equipped with DAD/VWD. 1 x equipped with column switcher. Used for method development and project support
	Agilent 1260 HPLC x 2	Agilent	Equipped with DAD and Masshunter open-access interface, for general project support
	Agilent 1260 HPLC-MS	Agilent	Equipped with 6150 mass spectrometer. Used for process development and optimisation
	Agilent 1290 UPLC	Agilent	Used for method development and optimisation
	Agilent 1290 UPLC x 2	Agilent	1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission
	Agilent 1290 UPLC-MS x 2	Agilent	1300 bar, 6 column switcher allows high throughput IPC analysis using generic methods across multiple projects. Masshunter open-access interface and automatic vial disposal provides simplified and optimised sample submission. iQ mass detector allows for process optimisation
	Agilent 6550LC/Q-TQF MS	Agilent	High Resolution Accurate Mass MS/MS instrument for Compound ID, analysis of large molecules (Oligos, Peptides, etc), trace analysis (GI’s and Nitrosamines) and complex mixture analysis
	Agilent 6550 iFunnel Q-Tof LC/MS	Agilent	High Resolution Accurate Mass MS/MS instrument for Compound ID, analysis of large molecules (Oligos, Peptides, etc), trace analysis (GI’s and Nitrosamines) and complex mixture analysis
	Waters ACQUITY I-Class UPLC-MS	Waters	Equipped with Triple Quadrupole Detector (TQD) and 4 column manager, used for rapid method screening, with open access software
	Waters ACQUITY H-Class UPLC-MS	Waters	Equipped with QDa mass detector, 4 column switcher with open access software
	Shimadzu LC20/30 HPLC	Shimadzu	Equipped with 6 way column switcher for rapid reverse-phase chiral screening system
	Thermo Vanquish Duo UPLC-CAD-MS x 2	Thermo	Equipped with CAD and DAD and dual pumps for reverse gradient. Applied to the quantification of compounds and impurities with poor chromophores
	Agilent 7890B GC-FID	Agilent	Equipped with dual Flame Ionisation Detector (FID) and dual injector
	Agilent 6890N GC-FID	Agilent	Equipped with dual Flame Ionisation Detector (FID), headspace sample injector
	Agilent 8890 GC-FID-MS	Agilent	Equipped with a single-quadropole MS for impurity identification
	Agilent 8890 FID-VUV	Agilent/VUV	Equipped with Flame ionisation Detector and Vacuum UV detector to allow analysis of trace levels including moisture, and solvents in a single analytical method
	Shimadzu i-series 2050 x 2	Shimadzu	Used for routine sample analysis (integrated with LabSolutions DCS)
	Shimadzu XS UPLC	Shimadzu	Used for rapid method screening and method optimisation
	Shimadzu LC40 LC-MS 2020	Shimadzu	Impurity identification (integrated with LabSolutions DCS)
	Shimadzu GC-MS 2020NX	Shimadzu	Also has FID detector. Impurity identification (integrated with LabSolutions DCS)
	Shimadzu GC OAC6000	Shimadzu	GC-FID system for routine sample analysis (integrated with LabSolutions DCS)
	Labsolutions	Shimadzu	Used for GMP chromatography data system
	Labware	Labware	Used for GMP LIMS/ELN
	Thermal Screening Unit	HEL	For identifying thermal and pressure hazards in reaction mixes and raw material liquids and powders
	JEOL 400MHz NMR	Jeol	Equipped with 30 place autosampler – Used for in-house process development, confirmation of structure and assay
	ICP-MS	Shimadzu	Residual metals analysis and ICHQ3D
	Agilent 1290 UPLC-QTOF	Agilent	Equipped with MS/MS capability, with a high-resolution TOF stage with, ability to analyse larger molecular weight compounds such as oligonucleotides
	Shimadzu Tm-UV	Shimadzu	UV instrument with temperature modifying capability to enable analysis of oligonucleotides
	Fusion	S-Matrix	Software platform which allows method development, analytical QbD and method robustness determination
Crystallisation, Solid State and Preformulation	Parallel Crystalliser – Crystal 16	Technobis	Used to build solubility curves. 16 parallel screens in volumes 0.5 – 1.5 mL
	Crystalline	Technobis	Crystallisation process design up to 8 mL with overhead stirring
	FTIR	Shimadzu	Used to confirm the identity of a material and to differentiate between polymorphs
	DSC	Mettler Toledo	Thermal and thermodynamic stability of materials with autosampler
	EquaVAP Evaporator	EquaVAP	Used to evaporate solvent from vials in plates
	XRPD	Malvern Panalytical	Identification of solid state forms
	VacMaster Filtration Unit	Biotage	Used to assess filtrations before scale-up
	TGA	Mettler Toledo	Levels of loosely bound solvent
	Hot Stage Microscope	Leica	Assessment of crystallinity, particle shape and size, and polymorph change at varying temperatures
	Microscope	Zeiss	High resolution assessment of crystallinity, particle shape and size
	Lab scale fluid energy mill	FPS	Used to control the size of seed used in crystallisation studies
	Tapped bulk density	Anton-Paar	Used to assess flowability of powders handled
	Malvern 3000 particle sizer	Malvern Panalytical	Particle size measurements
	Stability chambers	Camlab	Investigational stability of drug substance and drug product
	Stability oven	Memmert	Used to evaluate the stability of API over time under controlled temperature, humidity and light environments
	Blaze 900 probe	Blaze	Used for in-process particle characterisation by imaging and chord length distribution analysis
	Radley Reactor-Ready	Radley	Universal reactor work station with a range of easily interchangeable vessels from 250 mL to 5 L which can be configured to suit the chemistry and scale needed for each project
	microDISS Profiler	Pion	Used to measure the dissolution profiles of API in physilogic media
	DVS Intrinsic Plus	Surface Measurement Systems Ltd.	Gravimetric vapor sorption analyser used to measure the hygroscopicity of a solid
	Mya 4 Reaction Station	Radley	A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry.
Oligonucleotides PR&D	MerMade 12 Oligonucleotide Synthesiser	LGC	50 nmol to 200 µmol synthesis scale. Medium throughput synthesier with a 12 column configuration and 20 amidite positions.
	ÄKTA OligoSynt™	Cytiva	10 µmol to 12 mmol synthesis scale. Compact, fully automated oligonucleotide synthesizer with broad scale for robust and scalable process development and transfer to manufacturing
Oligonucleotides Analytical	Agilent 1290 Infinity II UPLC	Agilent
	Agilent 1290 Infinity II Prep-LC	Agilent
	Agilent AdvanceBio 6545XT QToF w/ BioConfirm	Agilent
	ThermoFisher NanoDrop One-C	ThermoFisher