Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of Solid Tumors: Lessons in Ortho-Bromination, Selective Solubility, Pd Deactivation, and Form Control
Org. Process Res. Dev. 2022, 26, 5, 1458–1469
By: Antonio M. Ruda, Nadia Fleary-Roberts, Jonathan D. Moseley and Siân M. Forsyth et al.